KIF3A: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Kinesin-like protein KIF3A''' is a [[protein]] that in humans is encoded by the ''KIF3A'' [[gene]].<ref name="pmid10548469">{{cite journal |vauthors=Whitehead JL, Wang SY, Bost-Usinger L, Hoang E, Frazer KA, Burnside B | title = Photoreceptor localization of the KIF3A and KIF3B subunits of the heterotrimeric microtubule motor kinesin II in vertebrate retina | journal = Exp. Eye Res. | volume = 69 | issue = 5 | pages = 491–503 |date=November 1999 | pmid = 10548469 | doi = 10.1006/exer.1999.0724 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KIF3A kinesin family member 3A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11127| accessdate = }}</ref>
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| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
KIF3A is one subunit of the [[protein trimer|heterotrimeric]] motor protein, [[kinesin]]-2, that was initially isolated from sea urchin egg/embryo [[cytosol]] using [[microtubule]] affinity purification.<ref name="pmid8232586">{{cite journal |vauthors=Cole DG, Chinn SW, Wedaman KP, Hall K, Vuong T, Scholey JM | title = Novel heterotrimeric kinesin-related protein purified from sea urchin eggs | journal = Nature | volume = 366 | issue = 6452 | pages = 268–70 |date=November 1993 | pmid = 8232586 | doi = 10.1038/366268a0 }}</ref> This motor consists of two kinesin-related subunits (called KIF3A and [[KIF3B]] or 3C in vertebrates) and an associated protein ([[KIFAP3|KAP3]]), and it transports protein complexes, nucleic acids and organelles towards the "plus" ends of microtubule tracks within cells. Work done in a broad range of eukaryotic cells has revealed that heterotrimeric kinesin-2 is the primary motor protein driving the intra-[[flagellum|flagellar]] transport of [[tubulin]]s and other [[axoneme|axonemal]] building blocks from the base of the ciliary/flagellar axoneme to their site of assembly at the distal tips.<ref name="pmid12415299">{{cite journal |vauthors=Rosenbaum JL, Witman GB | title = Intraflagellar transport | journal = Nat. Rev. Mol. Cell Biol. | volume = 3 | issue = 11 | pages = 813–25 |date=November 2002 | pmid = 12415299 | doi = 10.1038/nrm952 }}</ref> This process is required for cilium assembly/maintenance and [[cilium]]-based signalling which play key roles in various cell and developmental processes. For example, in vertebrate embryos, kinesin-2 function is required for cilia-dependent nodal flow and the development of left-right asymmetry.<ref name="pmid9865700">{{cite journal |vauthors=Nonaka S, Tanaka Y, Okada Y, Takeda S, Harada A, Kanai Y, Kido M, Hirokawa N | title = Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein | journal = Cell | volume = 95 | issue = 6 | pages = 829–37 |date=December 1998 | pmid = 9865700 | doi = 10.1016/S0092-8674(00)81705-5}}</ref>
| image =
| image_source =
| PDB =
| Name = Kinesin family member 3A
| HGNCid = 6319
| Symbol = KIF3A
| AltSymbols =;
| OMIM = 604683
| ECnumber = 
| Homologene = 38266
| MGIid = 107689
| GeneAtlas_image1 = PBB_GE_KIF3A_213623_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003777 |text = microtubule motor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}}
| Component = {{GNF_GO|id=GO:0005874 |text = microtubule}} {{GNF_GO|id=GO:0005875 |text = microtubule associated complex}}
| Process = {{GNF_GO|id=GO:0001822 |text = kidney development}} {{GNF_GO|id=GO:0006996 |text = organelle organization and biogenesis}} {{GNF_GO|id=GO:0007018 |text = microtubule-based movement}} {{GNF_GO|id=GO:0007368 |text = determination of left/right symmetry}} {{GNF_GO|id=GO:0009953 |text = dorsal/ventral pattern formation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11127
    | Hs_Ensembl = ENSG00000131437
    | Hs_RefseqProtein = NP_008985
    | Hs_RefseqmRNA = NM_007054
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 132056267
    | Hs_GenLoc_end = 132101229
    | Hs_Uniprot = Q9Y496
    | Mm_EntrezGene = 16568
    | Mm_Ensembl = ENSMUSG00000018395
    | Mm_RefseqmRNA = NM_008443
    | Mm_RefseqProtein = NP_032469
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 53410826
    | Mm_GenLoc_end = 53445390
    | Mm_Uniprot = Q3TET1
  }}
}}
'''Kinesin family member 3A''', also known as '''KIF3A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KIF3A kinesin family member 3A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11127| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
==Interactions==
{{PBB_Summary
KIF3A has been shown to [[Protein-protein interaction|interact]] with [[MAP3K10]].<ref name="pmid9427749">{{cite journal |vauthors=Nagata K, Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T, Hirokawa N, Hall A | title = The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3 | journal = EMBO J. | volume = 17 | issue = 1 | pages = 149–58 |date=January 1998 | pmid = 9427749 | pmc = 1170366 | doi = 10.1093/emboj/17.1.149 }}</ref>
| section_title =  
| summary_text =  
}}


==References==
==References==
{{reflist|2}}
{{Reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal   |vauthors=Aizawa H, Sekine Y, Takemura R, etal |title=Kinesin family in murine central nervous system. |journal=J. Cell Biol. |volume=119 |issue= 5 |pages= 1287–96 |year= 1992 |pmid= 1447303 |doi= 10.1083/jcb.119.5.1287| pmc=2289715 }}
| citations =
*{{cite journal  |vauthors=Yamazaki H, Nakata T, Okada Y, Hirokawa N |title=KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport. |journal=J. Cell Biol. |volume=130 |issue= 6 |pages= 1387–99 |year= 1995 |pmid= 7559760 |doi= 10.1083/jcb.130.6.1387| pmc=2120571 }}
*{{cite journal | author=Aizawa H, Sekine Y, Takemura R, ''et al.'' |title=Kinesin family in murine central nervous system. |journal=J. Cell Biol. |volume=119 |issue= 5 |pages= 1287-96 |year= 1992 |pmid= 1447303 |doi=  }}
*{{cite journal  |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Yamazaki H, Nakata T, Okada Y, Hirokawa N |title=KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport. |journal=J. Cell Biol. |volume=130 |issue= 6 |pages= 1387-99 |year= 1995 |pmid= 7559760 |doi=  }}
*{{cite journal   |vauthors=Nagata K, Puls A, Futter C, etal |title=The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3. |journal=EMBO J. |volume=17 |issue= 1 |pages= 149–58 |year= 1998 |pmid= 9427749 |doi= 10.1093/emboj/17.1.149 | pmc=1170366 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  |vauthors=Yang Z, Goldstein LS |title=Characterization of the KIF3C neural kinesin-like motor from mouse. |journal=Mol. Biol. Cell |volume=9 |issue= 2 |pages= 249–61 |year= 1998 |pmid= 9450952 |doi= 10.1091/mbc.9.2.249| pmc=25248 }}
*{{cite journal | author=Nagata K, Puls A, Futter C, ''et al.'' |title=The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3. |journal=EMBO J. |volume=17 |issue= 1 |pages= 149-58 |year= 1998 |pmid= 9427749 |doi= 10.1093/emboj/17.1.149 }}
*{{cite journal   |vauthors=Shimizu K, Shirataki H, Honda T, etal |title=Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide. |journal=J. Biol. Chem. |volume=273 |issue= 12 |pages= 6591–4 |year= 1998 |pmid= 9506951 |doi=10.1074/jbc.273.12.6591  }}
*{{cite journal  | author=Yang Z, Goldstein LS |title=Characterization of the KIF3C neural kinesin-like motor from mouse. |journal=Mol. Biol. Cell |volume=9 |issue= 2 |pages= 249-61 |year= 1998 |pmid= 9450952 |doi=  }}
*{{cite journal  |vauthors=Hasegawa T, Yagi A, Isobe K |title=Interaction between GADD34 and kinesin superfamily, KIF3A. |journal=Biochem. Biophys. Res. Commun. |volume=267 |issue= 2 |pages= 593–6 |year= 2000 |pmid= 10631107 |doi= 10.1006/bbrc.1999.1991 }}
*{{cite journal | author=Shimizu K, Shirataki H, Honda T, ''et al.'' |title=Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide. |journal=J. Biol. Chem. |volume=273 |issue= 12 |pages= 6591-4 |year= 1998 |pmid= 9506951 |doi= }}
*{{cite journal   |vauthors=Jimbo T, Kawasaki Y, Koyama R, etal |title=Identification of a link between the tumour suppressor APC and the kinesin superfamily. |journal=Nat. Cell Biol. |volume=4 |issue= 4 |pages= 323–7 |year= 2002 |pmid= 11912492 |doi= 10.1038/ncb779 }}
*{{cite journal  | author=Whitehead JL, Wang SY, Bost-Usinger L, ''et al.'' |title=Photoreceptor localization of the KIF3A and KIF3B subunits of the heterotrimeric microtubule motor kinesin II in vertebrate retina. |journal=Exp. Eye Res. |volume=69 |issue= 5 |pages= 491-503 |year= 1999 |pmid= 10548469 |doi= 10.1006/exer.1999.0724 }}
*{{cite journal  |vauthors=Aronov S, Aranda G, Behar L, Ginzburg I |title=Visualization of translated tau protein in the axons of neuronal P19 cells and characterization of tau RNP granules. |journal=J. Cell Sci. |volume=115 |issue= Pt 19 |pages= 3817–27 |year= 2003 |pmid= 12235292 |doi=10.1242/jcs.00058  }}
*{{cite journal | author=Hasegawa T, Yagi A, Isobe K |title=Interaction between GADD34 and kinesin superfamily, KIF3A. |journal=Biochem. Biophys. Res. Commun. |volume=267 |issue= 2 |pages= 593-6 |year= 2000 |pmid= 10631107 |doi= 10.1006/bbrc.1999.1991 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Jimbo T, Kawasaki Y, Koyama R, ''et al.'' |title=Identification of a link between the tumour suppressor APC and the kinesin superfamily. |journal=Nat. Cell Biol. |volume=4 |issue= 4 |pages= 323-7 |year= 2002 |pmid= 11912492 |doi= 10.1038/ncb779 }}
*{{cite journal  |vauthors=Surpili MJ, Delben TM, Kobarg J |title=Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1. |journal=Biochemistry |volume=42 |issue= 51 |pages= 15369–76 |year= 2004 |pmid= 14690447 |doi= 10.1021/bi034575v }}
*{{cite journal | author=Aronov S, Aranda G, Behar L, Ginzburg I |title=Visualization of translated tau protein in the axons of neuronal P19 cells and characterization of tau RNP granules. |journal=J. Cell. Sci. |volume=115 |issue= Pt 19 |pages= 3817-27 |year= 2003 |pmid= 12235292 |doi=  }}
*{{cite journal  |vauthors=Zhang Y, Hancock WO |title=The two motor domains of KIF3A/B coordinate for processive motility and move at different speeds. |journal=Biophys. J. |volume=87 |issue= 3 |pages= 1795–804 |year= 2005 |pmid= 15345558 |doi= 10.1529/biophysj.104.039842  | pmc=1304584 }}{{Retracted paper}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Schmutz J, Martin J, Terry A, etal |title=The DNA sequence and comparative analysis of human chromosome 5. |journal=Nature |volume=431 |issue= 7006 |pages= 268–74 |year= 2004 |pmid= 15372022 |doi= 10.1038/nature02919 }}
*{{cite journal  | author=Surpili MJ, Delben TM, Kobarg J |title=Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1. |journal=Biochemistry |volume=42 |issue= 51 |pages= 15369-76 |year= 2004 |pmid= 14690447 |doi= 10.1021/bi034575v }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Zhang Y, Hancock WO |title=The two motor domains of KIF3A/B coordinate for processive motility and move at different speeds. |journal=Biophys. J. |volume=87 |issue= 3 |pages= 1795-804 |year= 2005 |pmid= 15345558 |doi= 10.1529/biophysj.104.039842 }}
*{{cite journal   |vauthors=Brown CL, Maier KC, Stauber T, etal |title=Kinesin-2 is a motor for late endosomes and lysosomes. |journal=Traffic |volume=6 |issue= 12 |pages= 1114–24 |year= 2006 |pmid= 16262723 |doi= 10.1111/j.1600-0854.2005.00347.x }}
*{{cite journal | author=Schmutz J, Martin J, Terry A, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 5. |journal=Nature |volume=431 |issue= 7006 |pages= 268-74 |year= 2004 |pmid= 15372022 |doi= 10.1038/nature02919 }}
*{{cite journal   |vauthors=Haraguchi K, Hayashi T, Jimbo T, etal |title=Role of the kinesin-2 family protein, KIF3, during mitosis. |journal=J. Biol. Chem. |volume=281 |issue= 7 |pages= 4094–9 |year= 2006 |pmid= 16298999 |doi= 10.1074/jbc.M507028200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Camargo LM, Collura V, Rain JC, etal |title=Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. |journal=Mol. Psychiatry |volume=12 |issue= 1 |pages= 74–86 |year= 2007 |pmid= 17043677 |doi= 10.1038/sj.mp.4001880 }}
*{{cite journal | author=Brown CL, Maier KC, Stauber T, ''et al.'' |title=Kinesin-2 is a motor for late endosomes and lysosomes. |journal=Traffic |volume=6 |issue= 12 |pages= 1114-24 |year= 2006 |pmid= 16262723 |doi= 10.1111/j.1600-0854.2005.00347.x }}
*{{cite journal   |vauthors=Pantelidou M, Zographos SE, Lederer CW, etal |title=Differential expression of molecular motors in the motor cortex of sporadic ALS. |journal=Neurobiol. Dis. |volume=26 |issue= 3 |pages= 577–89 |year= 2007 |pmid= 17418584 |doi= 10.1016/j.nbd.2007.02.005 }}
*{{cite journal | author=Haraguchi K, Hayashi T, Jimbo T, ''et al.'' |title=Role of the kinesin-2 family protein, KIF3, during mitosis. |journal=J. Biol. Chem. |volume=281 |issue= 7 |pages= 4094-9 |year= 2006 |pmid= 16298999 |doi= 10.1074/jbc.M507028200 }}
*{{cite journal | author=Camargo LM, Collura V, Rain JC, ''et al.'' |title=Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. |journal=Mol. Psychiatry |volume=12 |issue= 1 |pages= 74-86 |year= 2007 |pmid= 17043677 |doi= 10.1038/sj.mp.4001880 }}
*{{cite journal | author=Pantelidou M, Zographos SE, Lederer CW, ''et al.'' |title=Differential expression of molecular motors in the motor cortex of sporadic ALS. |journal=Neurobiol. Dis. |volume=26 |issue= 3 |pages= 577-89 |year= 2007 |pmid= 17418584 |doi= 10.1016/j.nbd.2007.02.005 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Ciliary proteins}}
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{{Gene-5-stub}}

Latest revision as of 20:10, 8 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

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n/a

UniProt

n/a

n/a

RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Kinesin-like protein KIF3A is a protein that in humans is encoded by the KIF3A gene.[1][2]

Function

KIF3A is one subunit of the heterotrimeric motor protein, kinesin-2, that was initially isolated from sea urchin egg/embryo cytosol using microtubule affinity purification.[3] This motor consists of two kinesin-related subunits (called KIF3A and KIF3B or 3C in vertebrates) and an associated protein (KAP3), and it transports protein complexes, nucleic acids and organelles towards the "plus" ends of microtubule tracks within cells. Work done in a broad range of eukaryotic cells has revealed that heterotrimeric kinesin-2 is the primary motor protein driving the intra-flagellar transport of tubulins and other axonemal building blocks from the base of the ciliary/flagellar axoneme to their site of assembly at the distal tips.[4] This process is required for cilium assembly/maintenance and cilium-based signalling which play key roles in various cell and developmental processes. For example, in vertebrate embryos, kinesin-2 function is required for cilia-dependent nodal flow and the development of left-right asymmetry.[5]

Interactions

KIF3A has been shown to interact with MAP3K10.[6]

References

  1. ↑ Whitehead JL, Wang SY, Bost-Usinger L, Hoang E, Frazer KA, Burnside B (November 1999). "Photoreceptor localization of the KIF3A and KIF3B subunits of the heterotrimeric microtubule motor kinesin II in vertebrate retina". Exp. Eye Res. 69 (5): 491–503. doi:10.1006/exer.1999.0724. PMID 10548469.
  2. ↑ "Entrez Gene: KIF3A kinesin family member 3A".
  3. ↑ Cole DG, Chinn SW, Wedaman KP, Hall K, Vuong T, Scholey JM (November 1993). "Novel heterotrimeric kinesin-related protein purified from sea urchin eggs". Nature. 366 (6452): 268–70. doi:10.1038/366268a0. PMID 8232586.
  4. ↑ Rosenbaum JL, Witman GB (November 2002). "Intraflagellar transport". Nat. Rev. Mol. Cell Biol. 3 (11): 813–25. doi:10.1038/nrm952. PMID 12415299.
  5. ↑ Nonaka S, Tanaka Y, Okada Y, Takeda S, Harada A, Kanai Y, Kido M, Hirokawa N (December 1998). "Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein". Cell. 95 (6): 829–37. doi:10.1016/S0092-8674(00)81705-5. PMID 9865700.
  6. ↑ Nagata K, Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T, Hirokawa N, Hall A (January 1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. 17 (1): 149–58. doi:10.1093/emboj/17.1.149. PMC 1170366. PMID 9427749.

Further reading


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