XK (protein): Difference between revisions
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Revision as of 16:01, 6 September 2012
XK (protein) | |
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Identifiers | |
Symbol | XK |
Alt. symbols | XKR1, Kx, X1k |
Entrez | 7504 |
HUGO | 12811 |
OMIM | 314850 |
PDB | BAE48708 |
RefSeq | NM_021083 |
UniProt | P51811 |
Other data | |
Locus | Chr. X p21.2-p21.1 |
WikiDoc Resources for XK (protein) |
Articles |
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Most recent articles on XK (protein) Most cited articles on XK (protein) |
Media |
Powerpoint slides on XK (protein) |
Evidence Based Medicine |
Clinical Trials |
Ongoing Trials on XK (protein) at Clinical Trials.gov Clinical Trials on XK (protein) at Google
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Guidelines / Policies / Govt |
US National Guidelines Clearinghouse on XK (protein)
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Books |
News |
Commentary |
Definitions |
Patient Resources / Community |
Patient resources on XK (protein) Discussion groups on XK (protein) Patient Handouts on XK (protein) Directions to Hospitals Treating XK (protein) Risk calculators and risk factors for XK (protein)
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Healthcare Provider Resources |
Causes & Risk Factors for XK (protein) |
Continuing Medical Education (CME) |
International |
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Business |
Experimental / Informatics |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
XK (also known as Kell blood group precursor) is a protein found on human red blood cells and other tissues which is responsible for the Kx antigen which helps determine a person's blood type. The Kx antigen plays a role in matching blood for blood transfusions. Absence of XK protein leads to McLeod syndrome, a multi-system disorder characterized by hemolytic anemia, myopathy, acanthocytosis, and chorea. [1]
XK is located on the X chromosome and absence of the XK protein is an X-linked disease.[2] XK is a membrane transport protein of unknown action.[3]
References
- ↑ Malandrini A, Fabrizi GM, Truschi F, Di Pietro G, Moschini F, Bartalucci P, Berti G, Salvadori C, Bucalossi A, Guazzi G. Atypical McLeod syndrome manifested as X-linked chorea-acanthocytosis, neuromyopathy and dilated cardiomyopathy: report of a family. J Neurol Sci. 1994 Jun;124(1):89-94. PMID 7931427
- ↑ Ho MF, Monaco AP, Blonden LA, van Ommen GJ, Affara NA, Ferguson-Smith MA, Lehrach H. Fine mapping of the McLeod locus (XK) to a 150-380-kb region in Xp21. Am J Hum Genet. 1992 Feb;50(2):317-30. PMID 1734714
- ↑ Jung HH, Russo D, Redman C, Brandner S. Kell and XK immunohistochemistry in McLeod myopathy. Muscle Nerve. 2001 Oct;24(10):1346-51. PMID 11562915
External links
- XK at BGMUT Blood Group Antigen Gene Mutation Database at NCBI, NIH