Eczema causes: Difference between revisions

Jump to navigation Jump to search
No edit summary
 
(16 intermediate revisions by 3 users not shown)
Line 1: Line 1:
__NOTOC__
{{Eczema}}
{{Eczema}}
{{CMG}}, {{AE}} [[User:Edzelco|Edzel Lorraine Co, D.M.D., M.D.]]
{{CMG}}, {{AE}} {{EdzelCo}}


==Overview==
==Overview==
[[Eczema]] could be due to a [[genetic]] problem, or a result of the [[adverse effect]] of certain [[medication]].
The [[etiology]] of [[eczema]] is multifactorial and complex. This involves aberrations in [[genetic]] components, [[adverse effect]]s of certain [[medication]]s, and some environmental factors.


==Causes==
==Etiology of Eczema==
*Damage from the [[Enzyme|enzymatic]] activity of [[allergens]] is usually prevented by the body's own [[protease inhibitor]]s, such as, ''[[LEKTI]]'',  produced from the gene ''[[SPINK5]]''.
**[[Netherton’s syndrome]], a [[congenital]] condition presenting with [[erythroderma]], [[food allergy]], [[hay fever]], [[asthma]], and [[urticaria]], results from the [[mutation]] of this [[gene]]. <ref name="pmid11544479">{{cite journal |author=Walley AJ, Chavanas S, Moffatt MF, ''et al'' |title=Gene polymorphism in Netherton and common atopic disease |journal=Nat. Genet. |volume=29 |issue=2 |pages=175–8 |year=2001[[Mutations]] in this gene are known to cause  |pmid=11544479 |doi=10.1038/ng728}}</ref>


*Lack of [[filaggrin]] [[gene]] causes [[dry skin]] and impaired [[skin]] [[barrier]] [[function]]. <ref name=filaggrin>Palmer, C.N. ''et al.'' (2006) Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. ''Nature Genetics''  '''38'''(4), 441-6. PMID 16550169</ref>
===Genetic problem===
 
*Damage from the [[Enzyme|enzymatic]] activity of [[allergens]] is usually prevented by the body's own [[protease inhibitor]]s, such as ''[[LEKTI]]'',  produced from the gene ''[[SPINK5]]''.
===Common Medications with Eczema as the Adverse Drug Effect===
*Lack of [[filaggrin]] [[gene]] causes [[dry skin]]. <ref name="pmid16550169">{{cite journal| author=Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee SP | display-authors=etal| title=Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. | journal=Nat Genet | year= 2006 | volume= 38 | issue= 4 | pages= 441-6 | pmid=16550169 | doi=10.1038/ng1767 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16550169  }} </ref>


===Eczema as an Adverse Drug Reaction===
*[[Eczema]] can also be brought about by some adverse effects of [[medications]].
*Below is a list of commonly prescribed medications with [[eczema]] as the common [[adverse drug effect]] '''(Table 1)'''.
*Below is a list of commonly prescribed medications with [[eczema]] as the common [[adverse drug effect]] '''(Table 1)'''.


Line 19: Line 20:
{| style="border: 0px; font-size: 90%; margin: 1px; width: " align="center" 500px;"
{| style="border: 0px; font-size: 90%; margin: 1px; width: " align="center" 500px;"
| valign="top" |
| valign="top" |
|+<big>''' Table 1. More Common types of [[Eczema]].'''
|+<big>''' Table 1. List of [[medications]] with [[eczema]] as its [[adverse effect]].'''
! align="center" style="background: #00CED1; width: 500px;" |{{fontcolor|#FFF|[[Medication]]}}
! align="center" style="background: #00CED1; width: 500px;" |{{fontcolor|#FFF|[[Medication]]}}
|-
|-
Line 38: Line 39:
==References==
==References==
{{reflist|2}}
{{reflist|2}}
[[category:Up to Date]]

Latest revision as of 07:43, 13 November 2023

Eczema Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Eczema from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Social Impact

Future or Investigational Therapies

Case Studies

Case #1

Eczema On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Eczema

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Eczema

CDC on Eczema

Eczema in the news

Blogs on Eczema

Directions to Hospitals Treating Eczema

Risk calculators and risk factors for Eczema

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Edzel Lorraine Co, DMD, MD[2]

Overview

The etiology of eczema is multifactorial and complex. This involves aberrations in genetic components, adverse effects of certain medications, and some environmental factors.

Etiology of Eczema

Genetic problem

Eczema as an Adverse Drug Reaction


Table 1. List of medications with eczema as its adverse effect.
Medication
Cidofovir
Flurbiprofen
Olaparib
Siltuximab
Sorafenib
Tiagabine

References

  1. Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee SP; et al. (2006). "Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis". Nat Genet. 38 (4): 441–6. doi:10.1038/ng1767. PMID 16550169.