Thin basement membrane disease natural history, complications and prognosis: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Thin basement membrane disease}} | {{Thin basement membrane disease}} | ||
{{CMG}} | |||
{{AE}} {{MMT}} | |||
==Overview== | ==Overview== | ||
[[Thin basement membrane disease|TBMD]] is may developed or found incidentally in first decade of life in symptomatic patient, may present symptoms later in third decade in asymptomatic patient. If left untreated, adult [[Thin basement membrane disease|TBMD]] patients with [[proteinuria]] may develop [[hypertension]], [[renal impairment]] leading to [[renal insufficiency]]. [[Prognosis]] is usually good in patient with isolated [[hematuria]] in [[Thin basement membrane disease|TBMD]]. | |||
==Natural history, complications and prognosis== | ==Natural history, complications and prognosis== | ||
'''Natural History''' | '''Natural History''' | ||
*The symptoms of TBMD are usually developed in first decade of life and start with symptoms such as recurrent hematuria. It occurs rarely after age 50 years. | |||
*The symptoms of TBMD typically are not present initially, are found incidentally as microscopic hematuria, mild proteinuria in routine urine analysis and macroscopic hematuria rarely.<ref name="pmid19670702">{{cite journal |vauthors=Zurawski J, Salwa-Zurawska W, Woźniak A, Bortkiewicz E, Maciejewski J, Idasiak-Piechocka I, Urbański B |title=Clinical and morphological aspects of thin glomerular basement membrane disease |journal=Pol J Pathol |volume=60 |issue=1 |pages=35–42 |date=2009 |pmid=19670702 |doi= |url=}}</ref> | *The symptoms of [[Thin basement membrane disease|TBMD]] are usually developed in first decade of life and start with symptoms such as [[Benign Recurrent Hamaturia|recurrent hematuria]]. It occurs rarely after age 50 years. | ||
*If left untreated, adult TBMD patients with proteinuria may develop | *The symptoms of [[Thin basement membrane disease|TBMD]] typically are not present initially, are found incidentally as [[microscopic hematuria]], [[Proteinuria|mild proteinuria]] in [[Urinalysis|routine urine analysis]] and [[Hematuria|macroscopic hematuria]] rarely.<ref name="pmid19670702">{{cite journal |vauthors=Zurawski J, Salwa-Zurawska W, Woźniak A, Bortkiewicz E, Maciejewski J, Idasiak-Piechocka I, Urbański B |title=Clinical and morphological aspects of thin glomerular basement membrane disease |journal=Pol J Pathol |volume=60 |issue=1 |pages=35–42 |date=2009 |pmid=19670702 |doi= |url=}}</ref> | ||
*If left untreated, adult [[Thin basement membrane disease|TBMD]] patients with [[proteinuria]] may develop [[hypertension]], [[renal impairment]] leading to [[renal insufficiency]]. <ref name="pmid15880328">{{cite journal |vauthors=Tonna S, Wang YY, MacGregor D, Sinclair R, Martinello P, Power D, Savige J |title=The risks of thin basement membrane nephropathy |journal=Semin Nephrol |volume=25 |issue=3 |pages=171–5 |date=May 2005 |pmid=15880328 |doi=10.1016/j.semnephrol.2005.01.009 |url=}}</ref> | |||
'''Complication''' | '''Complication''' | ||
Common complications of TBMD include<ref name="pmid15880328">{{cite journal |vauthors=Tonna S, Wang YY, MacGregor D, Sinclair R, Martinello P, Power D, Savige J |title=The risks of thin basement membrane nephropathy |journal=Semin Nephrol |volume=25 |issue=3 |pages=171–5 |date=May 2005 |pmid=15880328 |doi=10.1016/j.semnephrol.2005.01.009 |url=}}</ref>: | Common complications of [[Thin basement membrane disease|TBMD]] include<ref name="pmid15880328">{{cite journal |vauthors=Tonna S, Wang YY, MacGregor D, Sinclair R, Martinello P, Power D, Savige J |title=The risks of thin basement membrane nephropathy |journal=Semin Nephrol |volume=25 |issue=3 |pages=171–5 |date=May 2005 |pmid=15880328 |doi=10.1016/j.semnephrol.2005.01.009 |url=}}</ref>: | ||
*Hypertension. | |||
*Proteinuria. | *[[Hypertension]]. | ||
*Renal impairment. | *[[Proteinuria]]. | ||
*Renal failure. | *[[Renal impairment|Renal impairment.]] | ||
*[[Renal failure|Renal failure.]] | |||
*Anxiety. | *Anxiety. | ||
'''Prognosis''' | '''Prognosis''' | ||
*Prognosis is good in patient with isolated hematuria. | |||
*The presence of proteinuria or other glomerulopathy is associated with a particularly poor prognosis among patients with TBMD.<ref name="pmid31288791">{{cite journal |vauthors=Hashimoto H, Ohashi N, Tsuji N, Naito Y, Isobe S, Fujikura T, Tsuji T, Kato A, Nozu K, Iijima K, Yasuda H |title=A case report of thin basement membrane nephropathy accompanied by sporadic glomerulocystic kidney disease |journal=BMC Nephrol |volume=20 |issue=1 |pages=248 |date=July 2019 |pmid=31288791 |pmc=6617628 |doi=10.1186/s12882-019-1451-6 |url=}}</ref><ref name="pmid15880329">{{cite journal |vauthors=Norby SM, Cosio FG |title=Thin basement membrane nephropathy associated with other glomerular diseases |journal=Semin Nephrol |volume=25 |issue=3 |pages=176–9 |date=May 2005 |pmid=15880329 |doi=10.1016/j.semnephrol.2005.01.010 |url=}}</ref> | *[[Prognosis]] is good in patient with isolated [[hematuria]]. | ||
*The presence of [[proteinuria]] or other [[glomerulopathy]] is associated with a particularly [[Prognosis|poor prognosis]] among patients with [[Thin basement membrane disease|TBMD]].<ref name="pmid31288791">{{cite journal |vauthors=Hashimoto H, Ohashi N, Tsuji N, Naito Y, Isobe S, Fujikura T, Tsuji T, Kato A, Nozu K, Iijima K, Yasuda H |title=A case report of thin basement membrane nephropathy accompanied by sporadic glomerulocystic kidney disease |journal=BMC Nephrol |volume=20 |issue=1 |pages=248 |date=July 2019 |pmid=31288791 |pmc=6617628 |doi=10.1186/s12882-019-1451-6 |url=}}</ref><ref name="pmid15880329">{{cite journal |vauthors=Norby SM, Cosio FG |title=Thin basement membrane nephropathy associated with other glomerular diseases |journal=Semin Nephrol |volume=25 |issue=3 |pages=176–9 |date=May 2005 |pmid=15880329 |doi=10.1016/j.semnephrol.2005.01.010 |url=}}</ref> | |||
==References== | ==References== |
Latest revision as of 09:39, 21 December 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Marufa Marium, M.B.B.S[2]
Overview
TBMD is may developed or found incidentally in first decade of life in symptomatic patient, may present symptoms later in third decade in asymptomatic patient. If left untreated, adult TBMD patients with proteinuria may develop hypertension, renal impairment leading to renal insufficiency. Prognosis is usually good in patient with isolated hematuria in TBMD.
Natural history, complications and prognosis
Natural History
- The symptoms of TBMD are usually developed in first decade of life and start with symptoms such as recurrent hematuria. It occurs rarely after age 50 years.
- The symptoms of TBMD typically are not present initially, are found incidentally as microscopic hematuria, mild proteinuria in routine urine analysis and macroscopic hematuria rarely.[1]
- If left untreated, adult TBMD patients with proteinuria may develop hypertension, renal impairment leading to renal insufficiency. [2]
Complication
Common complications of TBMD include[2]:
- Hypertension.
- Proteinuria.
- Renal impairment.
- Renal failure.
- Anxiety.
Prognosis
- Prognosis is good in patient with isolated hematuria.
- The presence of proteinuria or other glomerulopathy is associated with a particularly poor prognosis among patients with TBMD.[3][4]
References
- ↑ Zurawski J, Salwa-Zurawska W, Woźniak A, Bortkiewicz E, Maciejewski J, Idasiak-Piechocka I, Urbański B (2009). "Clinical and morphological aspects of thin glomerular basement membrane disease". Pol J Pathol. 60 (1): 35–42. PMID 19670702.
- ↑ 2.0 2.1 Tonna S, Wang YY, MacGregor D, Sinclair R, Martinello P, Power D, Savige J (May 2005). "The risks of thin basement membrane nephropathy". Semin Nephrol. 25 (3): 171–5. doi:10.1016/j.semnephrol.2005.01.009. PMID 15880328.
- ↑ Hashimoto H, Ohashi N, Tsuji N, Naito Y, Isobe S, Fujikura T, Tsuji T, Kato A, Nozu K, Iijima K, Yasuda H (July 2019). "A case report of thin basement membrane nephropathy accompanied by sporadic glomerulocystic kidney disease". BMC Nephrol. 20 (1): 248. doi:10.1186/s12882-019-1451-6. PMC 6617628 Check
|pmc=
value (help). PMID 31288791. - ↑ Norby SM, Cosio FG (May 2005). "Thin basement membrane nephropathy associated with other glomerular diseases". Semin Nephrol. 25 (3): 176–9. doi:10.1016/j.semnephrol.2005.01.010. PMID 15880329.