Diabetes mellitus type 2 surgery: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
Line 5: | Line 5: | ||
[[Pancreas]] and [[Islets of Langerhans|islet cell]] [[Organ transplant|transplantation]] is considered in patients with chronic [[diabetes]] who have frequent [[metabolic]] [[complication (medicine)|complications]] and are intolerant to exogenous [[insulin]] or have failed [[insulin]] [[therapy]]. | [[Pancreas]] and [[Islets of Langerhans|islet cell]] [[Organ transplant|transplantation]] is considered in patients with chronic [[diabetes]] who have frequent [[metabolic]] [[complication (medicine)|complications]] and are intolerant to exogenous [[insulin]] or have failed [[insulin]] [[therapy]]. | ||
==Surgery== | ==Surgery== | ||
*There is no indication for [[surgery]] in [[type 2 diabetes mellitus]] unless, there is an [[indication]] for [[pancreas]] and [[Islets of Langerhans|islet cell]] [[Organ transplant|transplantation]]. [[Pancreas]] and [[Islets of Langerhans|islet cell]] [[Organ transplant|transplantation]] have been shown to normalize [[glucose]] levels but require lifelong [[immunosuppression]] to prevent [[Transplant rejection|graft rejection]] and recurrence of autoimmune islet destruction. [[Islets of Langerhans|Islet cell]] [[Organ transplant|transplantation]] remains investigational | *There is no indication for [[surgery]] in [[type 2 diabetes mellitus]] unless, there is an [[indication]] for [[pancreas]] and [[Islets of Langerhans|islet cell]] [[Organ transplant|transplantation]]. [[Pancreas transplantation]] is considered for patients with chronic [[diabetes]] and multiple [[complication (medicine)|complications]]. | ||
*[[Pancreas]] and [[Islets of Langerhans|islet cell]] [[Organ transplant|transplantation]] have been shown to normalize [[glucose]] levels but require lifelong [[immunosuppression]] to prevent [[Transplant rejection|graft rejection]] and recurrence of autoimmune islet destruction. | |||
*[[Islets of Langerhans|Islet cell]] [[Organ transplant|transplantation]] remains investigational. | |||
*Indication for pancreas transplantation is:<ref name="pmid16567844">{{cite journal |vauthors=Robertson RP, Davis C, Larsen J, Stratta R, Sutherland DE |title=Pancreas and islet transplantation in type 1 diabetes |journal=Diabetes Care |volume=29 |issue=4 |pages=935 |year=2006 |pmid=16567844 |doi= |url=}}</ref> | *Indication for pancreas transplantation is:<ref name="pmid16567844">{{cite journal |vauthors=Robertson RP, Davis C, Larsen J, Stratta R, Sutherland DE |title=Pancreas and islet transplantation in type 1 diabetes |journal=Diabetes Care |volume=29 |issue=4 |pages=935 |year=2006 |pmid=16567844 |doi= |url=}}</ref> | ||
**Patients who have history of frequent severe metabolic derangement ([[hypoglycemia]], marked [[hyperglycemia]], [[ketoacidosis]]), | **Patients who have history of frequent severe metabolic derangement ([[hypoglycemia]], marked [[hyperglycemia]], [[ketoacidosis]]), | ||
**Intolerant to exogenous [[insulin]] [[therapy]] | |||
**Failure of treatment with [[insulin]]. | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} |
Latest revision as of 20:16, 11 August 2020
Diabetes mellitus type 2 Microchapters |
Differentiating Diabetes Mellitus Type 2 from other Diseases |
Diagnosis |
Treatment |
Medical therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Seyedmahdi Pahlavani, M.D. [2]
Overview
Pancreas and islet cell transplantation is considered in patients with chronic diabetes who have frequent metabolic complications and are intolerant to exogenous insulin or have failed insulin therapy.
Surgery
- There is no indication for surgery in type 2 diabetes mellitus unless, there is an indication for pancreas and islet cell transplantation. Pancreas transplantation is considered for patients with chronic diabetes and multiple complications.
- Pancreas and islet cell transplantation have been shown to normalize glucose levels but require lifelong immunosuppression to prevent graft rejection and recurrence of autoimmune islet destruction.
- Islet cell transplantation remains investigational.
- Indication for pancreas transplantation is:[1]
- Patients who have history of frequent severe metabolic derangement (hypoglycemia, marked hyperglycemia, ketoacidosis),
- Intolerant to exogenous insulin therapy
- Failure of treatment with insulin.