Diabetes mellitus type 2 future or investigational therapies
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Anahita Deylamsalehi, M.D.[2]
Overview
There are some limited data supporting cannabis as a potential therapeutic agent for diabetes mellitus type 2. These studies suggest that there is a relationship between cannabinoids and lower rate of obesity and diabetes mellitus type 2. Since these data are restricted, more study is required regards this potential therapy.
Future or Investigational Therapies
- A randomized, double-blind, placebo-controlled study done on type 2 diabetic patients with cannabis use showed possible therapeutic effect on diabetes mellitus type 2. Δ(9)-tetrahydrocannabivarin (THCV) in cannabis was related to lower fasting blood sugar (FBS), better pancreatic beta cell function, improved adiponectin and apolipoprotein A, compared to placebo group. On the contrary, THCV had not any effect on HDL cholesterol.[1]
- Another study that investigated 579 of current cannabis users and 1975 of previous cannabis users, concluded that cannabis use is related to lower level of insulin in fasting state, lower Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and smaller waist circumference.[2]
References
- ↑ Jadoon KA, Ratcliffe SH, Barrett DA, Thomas EL, Stott C, Bell JD; et al. (2016). "Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study". Diabetes Care. 39 (10): 1777–86. doi:10.2337/dc16-0650. PMID 27573936.
- ↑ Penner EA, Buettner H, Mittleman MA (2013). "The impact of marijuana use on glucose, insulin, and insulin resistance among US adults". Am J Med. 126 (7): 583–9. doi:10.1016/j.amjmed.2013.03.002. PMID 23684393.