Cholera history and symptoms: Difference between revisions
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==Overview== | ==Overview== | ||
Patient may | Patient may have a history of consumption of contaminated food or water and/or travel to an [[endemic]] area. Cholera symptoms usually develop within 24-48 hour of infection. Patients present with sudden-onset, painless, odorless, rice-watery, large-volume stool; [[abdominal cramps]]; [[vomiting]]; and [[fever]]. If the severe [[diarrhea]] and [[vomiting]] are not aggressively treated, they can result in life-threatening [[dehydration]] and [[electrolyte imbalance|electrolyte imbalances]] within hours. The typical symptoms of [[dehydration]] include [[dizziness]] (due to low [[blood pressure]]), wrinkled hands (due to poor skin turgor), sunken eyes, [[muscle cramps]] (due to [[hypokalemia]]), and [[oliguria|decreased urine output]].<ref name="pmid14738797">{{cite journal| author=Sack DA, Sack RB, Nair GB, Siddique AK| title=Cholera. | journal=Lancet | year= 2004 | volume= 363 | issue= 9404 | pages= 223-33 | pmid=14738797 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14738797 }} </ref><ref name="pmid19842974">{{cite journal| author=Weil AA, Khan AI, Chowdhury F, Larocque RC, Faruque AS, Ryan ET et al.| title=Clinical outcomes in household contacts of patients with cholera in Bangladesh. | journal=Clin Infect Dis | year= 2009 | volume= 49 | issue= 10 | pages= 1473-9 | pmid=19842974 | doi=10.1086/644779 | pmc=2783773 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19842974 }} </ref><ref name="pmid7235397">{{cite journal| author=Morris JG, Wilson R, Davis BR, Wachsmuth IK, Riddle CF, Wathen HG et al.| title=Non-O group 1 Vibrio cholerae gastroenteritis in the United States: clinical, epidemiologic, and laboratory characteristics of sporadic cases. | journal=Ann Intern Med | year= 1981 | volume= 94 | issue= 5 | pages= 656-8 | pmid=7235397 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7235397 }} </ref> | ||
==History and Symptoms== | ==History and Symptoms== | ||
===History=== | ===History=== | ||
Cholera patients' histories may include consumption of contaminated food/water and/or recent travel to a cholera endemic area | Cholera patients' histories may include consumption of contaminated food/water and/or recent travel to a cholera-[[endemic]] area. Symptoms usually develop 24-48 hours after infection. | ||
===Symptoms=== | ===Symptoms=== | ||
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Symptoms of cholera include the following:<ref name="pmid14738797">{{cite journal| author=Sack DA, Sack RB, Nair GB, Siddique AK| title=Cholera. | journal=Lancet | year= 2004 | volume= 363 | issue= 9404 | pages= 223-33 | pmid=14738797 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14738797 }} </ref><ref name="pmid19842974">{{cite journal| author=Weil AA, Khan AI, Chowdhury F, Larocque RC, Faruque AS, Ryan ET et al.| title=Clinical outcomes in household contacts of patients with cholera in Bangladesh. | journal=Clin Infect Dis | year= 2009 | volume= 49 | issue= 10 | pages= 1473-9 | pmid=19842974 | doi=10.1086/644779 | pmc=2783773 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19842974 }} </ref><ref name="pmid7235397">{{cite journal| author=Morris JG, Wilson R, Davis BR, Wachsmuth IK, Riddle CF, Wathen HG et al.| title=Non-O group 1 Vibrio cholerae gastroenteritis in the United States: clinical, epidemiologic, and laboratory characteristics of sporadic cases. | journal=Ann Intern Med | year= 1981 | volume= 94 | issue= 5 | pages= 656-8 | pmid=7235397 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7235397 }} </ref> | Symptoms of cholera include the following:<ref name="pmid14738797">{{cite journal| author=Sack DA, Sack RB, Nair GB, Siddique AK| title=Cholera. | journal=Lancet | year= 2004 | volume= 363 | issue= 9404 | pages= 223-33 | pmid=14738797 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14738797 }} </ref><ref name="pmid19842974">{{cite journal| author=Weil AA, Khan AI, Chowdhury F, Larocque RC, Faruque AS, Ryan ET et al.| title=Clinical outcomes in household contacts of patients with cholera in Bangladesh. | journal=Clin Infect Dis | year= 2009 | volume= 49 | issue= 10 | pages= 1473-9 | pmid=19842974 | doi=10.1086/644779 | pmc=2783773 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19842974 }} </ref><ref name="pmid7235397">{{cite journal| author=Morris JG, Wilson R, Davis BR, Wachsmuth IK, Riddle CF, Wathen HG et al.| title=Non-O group 1 Vibrio cholerae gastroenteritis in the United States: clinical, epidemiologic, and laboratory characteristics of sporadic cases. | journal=Ann Intern Med | year= 1981 | volume= 94 | issue= 5 | pages= 656-8 | pmid=7235397 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7235397 }} </ref> | ||
====Diarrhea==== | ====[[Diarrhea]]==== | ||
* Sudden-onset | * Sudden-onset | ||
* Painless | * Painless | ||
* Odorless | * Odorless | ||
* Watery consistency (initially it may have some fecal matter but with disease progression stool becomes mostly watery) | * Watery consistency (initially it may have some fecal matter but with disease progression stool becomes mostly watery) | ||
* It is pale white in color and thus is sometimes referred as | * It is pale white in color and thus is sometimes referred as "rice-water stool" (has a similar color and consistency as water left after washing rice) | ||
* Voluminous (stool volume during cholera is more than that of any other infectious diarrhea causing uncontrolled bowel movements) | * Voluminous (stool volume during [[cholera]] is more than that of any other infectious, diarrhea-causing uncontrolled bowel movements) | ||
** An untreated person with cholera may produce 10–20 | ** An untreated person with cholera may produce 10–20 liters of [[diarrhea]] a day (with fatal results) | ||
* [[Abdominal cramps]] (due to large volume of intestinal secretion) | * [[Abdominal cramps]] (due to large volume of intestinal secretion) | ||
====Vomiting==== | ====Vomiting==== | ||
* | * Caused by decreased intestinal motility and [[acidemia]] | ||
====Muscle Cramp==== | ====Muscle Cramp==== | ||
* If | * If severe [[diarrhea]] and [[vomiting]] are not appropriately treated, they can result in life-threatening [[dehydration]] and [[electrolyte imbalance|electrolyte imbalances]] within hours | ||
* [[Cholera]] has been nicknamed the '''blue death''' due to a patient's skin turning a bluish-gray hue from extreme loss of fluids | ** Typical symptoms of [[dehydration]] include [[dizziness]] (due to low [[blood pressure]]), wrinkled hands (due to poor skin turgor), sunken eyes, [[muscle cramps]] (due to [[hypokalemia]]), and [[oliguria|decreased urine output]] | ||
* [[Cholera]] has been nicknamed the '''blue death''' due to a patient's skin turning a bluish-gray hue from extreme loss of fluids<ref>McElroy, Ann and Patricia K. Townsend. Medical Anthropology in Ecological Perspective. Boulder, CO: Westview, 2009, 375.</ref> | |||
====Fever==== | ====Fever==== | ||
* [[Fever]] is usually absent | * [[Fever]] is usually absent | ||
Other minor symptoms include excessive thirst, [[fatigue]], [[oliguria]] and [[weakness]]. For every symptomatic person, three to 100 people get the infection but remain asymptomatic<ref>{{cite journal |author=King AA, Ionides EL, J.Luckhurst, Bouma MJ |title=Inapparent infections and cholera dynamics |journal=Nature |volume=454 |issue=7206 |pages=877–80 |year=2008 |month=August |pmid=18704085 |doi=10.1038/nature07084 |url=}}</ref> | Other minor symptoms include excessive thirst, [[fatigue]], [[oliguria]], and [[weakness]]. For every symptomatic person, three to 100 people get the infection but remain [[asymptomatic]].<ref>{{cite journal |author=King AA, Ionides EL, J.Luckhurst, Bouma MJ |title=Inapparent infections and cholera dynamics |journal=Nature |volume=454 |issue=7206 |pages=877–80 |year=2008 |month=August |pmid=18704085 |doi=10.1038/nature07084 |url=}}</ref> | ||
== References == | == References == | ||
{{Reflist|2}} | {{Reflist|2}} | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editors-In-Chief: Priyamvada Singh, MBBS [2]
Overview
Patient may have a history of consumption of contaminated food or water and/or travel to an endemic area. Cholera symptoms usually develop within 24-48 hour of infection. Patients present with sudden-onset, painless, odorless, rice-watery, large-volume stool; abdominal cramps; vomiting; and fever. If the severe diarrhea and vomiting are not aggressively treated, they can result in life-threatening dehydration and electrolyte imbalances within hours. The typical symptoms of dehydration include dizziness (due to low blood pressure), wrinkled hands (due to poor skin turgor), sunken eyes, muscle cramps (due to hypokalemia), and decreased urine output.[1][2][3]
History and Symptoms
History
Cholera patients' histories may include consumption of contaminated food/water and/or recent travel to a cholera-endemic area. Symptoms usually develop 24-48 hours after infection.
Symptoms
Symptoms of cholera include the following:[1][2][3]
Diarrhea
- Sudden-onset
- Painless
- Odorless
- Watery consistency (initially it may have some fecal matter but with disease progression stool becomes mostly watery)
- It is pale white in color and thus is sometimes referred as "rice-water stool" (has a similar color and consistency as water left after washing rice)
- Voluminous (stool volume during cholera is more than that of any other infectious, diarrhea-causing uncontrolled bowel movements)
- An untreated person with cholera may produce 10–20 liters of diarrhea a day (with fatal results)
- Abdominal cramps (due to large volume of intestinal secretion)
Vomiting
- Caused by decreased intestinal motility and acidemia
Muscle Cramp
- If severe diarrhea and vomiting are not appropriately treated, they can result in life-threatening dehydration and electrolyte imbalances within hours
- Typical symptoms of dehydration include dizziness (due to low blood pressure), wrinkled hands (due to poor skin turgor), sunken eyes, muscle cramps (due to hypokalemia), and decreased urine output
- Cholera has been nicknamed the blue death due to a patient's skin turning a bluish-gray hue from extreme loss of fluids[4]
Fever
- Fever is usually absent
Other minor symptoms include excessive thirst, fatigue, oliguria, and weakness. For every symptomatic person, three to 100 people get the infection but remain asymptomatic.[5]
References
- ↑ 1.0 1.1 Sack DA, Sack RB, Nair GB, Siddique AK (2004). "Cholera". Lancet. 363 (9404): 223–33. PMID 14738797.
- ↑ 2.0 2.1 Weil AA, Khan AI, Chowdhury F, Larocque RC, Faruque AS, Ryan ET; et al. (2009). "Clinical outcomes in household contacts of patients with cholera in Bangladesh". Clin Infect Dis. 49 (10): 1473–9. doi:10.1086/644779. PMC 2783773. PMID 19842974.
- ↑ 3.0 3.1 Morris JG, Wilson R, Davis BR, Wachsmuth IK, Riddle CF, Wathen HG; et al. (1981). "Non-O group 1 Vibrio cholerae gastroenteritis in the United States: clinical, epidemiologic, and laboratory characteristics of sporadic cases". Ann Intern Med. 94 (5): 656–8. PMID 7235397.
- ↑ McElroy, Ann and Patricia K. Townsend. Medical Anthropology in Ecological Perspective. Boulder, CO: Westview, 2009, 375.
- ↑ King AA, Ionides EL, J.Luckhurst, Bouma MJ (2008). "Inapparent infections and cholera dynamics". Nature. 454 (7206): 877–80. doi:10.1038/nature07084. PMID 18704085. Unknown parameter
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