Acute lymphoblastic leukemia: Difference between revisions

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Latest revision as of 01:57, 21 March 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Umar Ahmad, M.D.[2] Raviteja Guddeti, M.B.B.S. [3] Carlos A Lopez, M.D. [4]

Synonyms and keywords: Acute lymphocytic leukemia, Acute lymphoid leukemia, ALL

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Acute lymphoblastic leukemia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Treatment

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 __NOTOC__
-{{Infobox_Disease |
- Name = Acute lymphoblastic leukemia |
- Image = acute_leukemia-ALL.jpg |
-}}
 {{Acute lymphoblastic leukemia}}
 '''For patient information click [[Leukemia (patient information)|here]]'''
-{{CMG}}; {{AE}} {{RT}} {{CLG}}
+{{CMG}}; {{AE}} {{UA}} {{RT}} {{CLG}}
 {{SK}} Acute lymphocytic leukemia, Acute lymphoid leukemia, ALL
 ==[[Acute lymphoblastic leukemia overview|Overview]]==
-Acute lymphoblastic leukemia was first described in 1827 by a french physician named [[Alfred-Armand-Louis-Marie Velpeau]].
-==[[Historical perspective]]==
+==[[Acute lymphoblastic leukemia historical perspective|Historical Perspective]]==
-* The first published description of a case of leukemia in medical literature dates to 1827, when a French physician named [[Alfred-Armand-Louis-Marie Velpeau]] described a 63-year-old florist who developed an illness characterized by [[fever]], [[weakness]], [[nephrolithiasis|urinary stones]], and substantial [[hepatosplenomegaly|enlargement of the liver and spleen]].  Velpeau noted that the blood of this patient had a consistency "like gruel", and speculated that the appearance of the blood was due to white corpuscles.<ref>
-{{cite book |last = Hoffman |first = Ronald ''et al.'' |title= Hematology: Basic Principles and Practice |year= 2005 |publisher= Elsevier Churchill Livingstone |location= St. Louis, Mo. |edition = 4th. ed. |pages = p. 1071 |id= ISBN 0-443-06629-9}}</ref>
-* In 1845, a series of patients who died with enlarged spleens and changes in the "colors and consistencies of their blood" was reported by the Edinburgh-based [[pathologist]] J.H. Bennett; he used the term "leucocythemia" to describe this pathological condition.<ref>Bennett JH. Two cases of hypertrophy of the spleen and liver, in which death took place from suppuration of blood. ''Edinburgh Med Surg J.'' (1845)64:413.</ref>
-* The term "leukemia" was coined by [[Rudolf Virchow]], the renowned German [[pathologist]], in 1856.  As a pioneer in the use of the [[light microscope]] in pathology, Virchow was the first to describe the abnormal excess of white blood cells in patients with the clinical syndrome described by Velpeau and Bennett.  As Virchow was uncertain of the [[etiology|cause]] of the white blood cell excess, he used the purely descriptive term "leukemia" (Greek: "white blood") to refer to the condition.<ref>Virchow R: Die Leukämie. In Virchow R (ed): Gesammelte Abhandlungen zur Wissenschaftlichen Medizin. Frankfurt, Meidinger, 1856, p 190.</ref>
-* [[Wilhelm Ebstein]] introduced the term ''"acute leukemia"'' in 1889 to differentiate rapidly progressive and fatal leukemias from the more indolent [[chronic leukemia]]s.<ref>Ebstein W. Ueber die acute Leukämie und Pseudoleukämie. ''Deutsch Arch Klin Med''. (1889)44:343.</ref>
-* The technique of [[bone marrow examination]] to diagnose leukemia was first described in 1879 by Mosler.<ref>Mosler F. Klinische Symptome und Therapie der medullären Leukämie. ''Berl Klin Wochenschr''. (1876)13:702. </ref>
-* Finally, in 1900 the [[lymphoblast]], which is the malignant cell in acute lymphoid leukemia, was characterized by Naegeli, who divided the leukemias into ''myeloid'' and ''lymphocytic''.<ref>Naegeli O. Über rothes Knochenmark und Myeloblasten. ''Deutsch Med Wochenschr''. (1900) 26:287.</ref><ref>{{cite journal | author = Zhen-yi, Wang |title = Ham-Wasserman Lecture: Treatment of Acute Leukemia by Inducing Differentiation and Apoptosis | year=2003 | journal = Hematology | pmid = 14633774}}</ref>
 ==[[Acute lymphoblastic leukemia classification|Classification]]==
 ==[[Acute lymphoblastic leukemia pathophysiology|Pathophysiology]]==
+==[[Acute lymphoblastic leukemia causes|Causes]]==
 ==[[Acute lymphoblastic leukemia differential diagnosis|Differentiating Acute lymphoblastic leukemia from other Diseases]]==
@@ Line 46: / Line 31: @@
 ==Diagnosis==
-[[Acute lymphoblastic leukemia history and symptoms|History and Symptoms ]] | [[ Acute lymphoblastic leukemia physical examination|Physical Examination]] | [[Acute lymphoblastic leukemia laboratory findings|Laboratory Findings]] | [[Acute lymphoblastic leukemia electrocardiogram|Electrocardiogram]] | [[Acute lymphoblastic leukemia CT|CT ]] | [[Acute lymphoblastic leukemia MRI|MRI]] | [[Acute lymphoblastic leukemia other imaging findings|Other Imaging Findings]] | [[Acute lymphoblastic leukemia other diagnostic studies|Other Diagnostic Studies]]
+[[Acute lymphoblastic leukemia diagnostic study of choice|Diagnostic Study of Choice]] | [[Acute lymphoblastic leukemia history and symptoms|History and Symptoms ]] | [[ Acute lymphoblastic leukemia physical examination|Physical Examination]] | [[Acute lymphoblastic leukemia laboratory findings|Laboratory Findings]] | [[Acute lymphoblastic leukemia electrocardiogram|Electrocardiogram]] | [[Acute lymphoblastic leukemia chest x ray|Chest X Ray]] | [[Acute lymphoblastic leukemia echocardiograph and ultrasound|Echocardiograph and Ultrasound]] | [[Acute lymphoblastic leukemia CT|CT ]] | [[Acute lymphoblastic leukemia MRI|MRI]] | [[Acute lymphoblastic leukemia other imaging findings|Other Imaging Findings]] | [[Acute lymphoblastic leukemia other diagnostic studies|Other Diagnostic Studies]]
 ==Treatment==
-[[Acute lymphoblastic leukemia medical therapy|Medical Therapy]] | [[Acute lymphoblastic leukemia primary prevention|Primary Prevention]] | [[Acute lymphoblastic leukemia secondary prevention|Secondary Prevention]] | [[Acute lymphoblastic leukemia cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Acute lymphoblastic leukemia future or investigational therapies|Future or Investigational Therapies]]
+[[Acute lymphoblastic leukemia medical therapy|Medical Therapy]] | [[Acute lymphoblastic leukemia surgery|Surgery]] | [[Acute lymphoblastic leukemia primary prevention|Primary Prevention]] | [[Acute lymphoblastic leukemia secondary prevention|Secondary Prevention]] | [[Acute lymphoblastic leukemia cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Acute lymphoblastic leukemia future or investigational therapies|Future or Investigational Therapies]]
 {{Hematology}}
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 [[Category:Types of cancer]]
 [[Category:Oncology]]
-[[Category:Overview complete]]
 {{WikiDoc Help Menu}}
 {{WikiDoc Sources}}
+ [[Category:Up-To-Date]]
+[[Category:Oncology]]
+[[Category:Medicine]]
+[[Category:Hematology]]
+[[Category:Immunology]]

v t e Myeloid Hematological malignancy/leukemia histology (ICD-O 9590-9989, C81-C96, 200-208)
CFU-GM/ and other granulocytes	Template:Navbox subgroup
MEP	Template:Navbox subgroup
CFU-Mast	Mastocytoma (Mast cell leukemia, Mast cell sarcoma, Systemic mastocytosis)
Multiple/unknown	AML (Acute panmyelosis with myelofibrosis, Myeloid sarcoma) · MP (Myelofibrosis) · Acute biphenotypic leukaemia
See also hematology, lymphoid malignancy

Acute lymphoblastic leukemia: Difference between revisions

Latest revision as of 01:57, 21 March 2020

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