Sexcord/ stromal ovarian tumors natural history, complications and prognosis: Difference between revisions
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{{Sexcord/ stromal ovarian tumors}} | {{Sexcord/ stromal ovarian tumors}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}};{{M.N}} | ||
==Overview== | ==Overview== | ||
The [[symtoms]] of sexcord/ stromal ovarian tumors include [[Adnexal mass causes|Adnexal mass]], [[Abdominal]] & [[pelvic]] [[symptoms]], [[Bloating]], [[Urinary urgency]] or [[frequency]], [[Dysphagia]](difficulty)[[eating]]) or feeling full quickly, [[Pelvic pain|Pelvic]] or [[abdominal pain]]. Common complications of sexcord/ stromal ovarian tumors include [[malignant]] [[pleural effusion]],[[bowel obstruction]],[[ascites]]. The [[prognosis]] varies with the subtypes of [[tumor]]. Most sexcord-stromal ovarian tumors present at a low [[tumor]] [[Cancer staging|stage]] and also [[prognosis]] in these [[patients]] is excellent. | |||
==Natural History, Complications, and Prognosis== | ==Natural History, Complications, and Prognosis== | ||
===Natural History=== | ===Natural History=== | ||
*The symptoms of sexcord/ stromal ovarian tumors usually develop in the second/ third/ fourth decade of life, and start with symptoms such as: | *The [[symptoms]] of sexcord/ stromal ovarian tumors usually develop in the second/ third/ fourth decade of life, and start with [[symptoms]] such as:<ref name="pmid19809549">{{cite journal |vauthors=Ayhan A, Salman MC, Velipasaoglu M, Sakinci M, Yuce K |title=Prognostic factors in adult granulosa cell tumors of the ovary: a retrospective analysis of 80 cases |journal=J Gynecol Oncol |volume=20 |issue=3 |pages=158–63 |date=September 2009 |pmid=19809549 |doi=10.3802/jgo.2009.20.3.158 |url=}}</ref> | ||
**Adnexal mass | **[[Adnexal mass causes|Adnexal mass]] | ||
**Abdominal & pelvic symptoms | **[[Abdominal]] & [[pelvic]] [[symptoms]] | ||
**Bloating | **[[Bloating]] | ||
**Urinary urgency or frequency | **[[Urinary urgency]] or [[frequency]] | ||
**Dysphagia(difficulty eating) or feeling full quickly | **[[Dysphagia]](difficulty [[eating]]) or feeling full quickly | ||
**Pelvic | **[[Pelvic pain|Pelvic]] or [[abdominal pain]] | ||
===Complications=== | ===Complications=== | ||
*Common complications of | *Common complications of sexcord/ stromal ovarian tumors include: | ||
**[ | **[[Malignant]] [[pleural effusion]] | ||
**[ | **[[Bowel obstruction]] | ||
**[ | **[[Ascites]] | ||
===Prognosis=== | ===Prognosis=== | ||
*Depending on the extent of the tumor at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as excellent<ref name="pmid16050568">{{cite journal |vauthors=Schneider DT, Calaminus G, Harms D, Göbel U |title=Ovarian sex cord-stromal tumors in children and adolescents |journal=J Reprod Med |volume=50 |issue=6 |pages=439–46 |date=June 2005 |pmid=16050568 |doi= |url=}}</ref><ref name="pmid24416992">{{cite journal |vauthors=Elashry R, Hemida R, Goda H, Abdel-Hady el-S |title=Prognostic factors of germ cell and sex cord-stromal ovarian tumors in pediatric age: 5 years experience |journal=J. Exp. Ther. Oncol. |volume=10 |issue=3 |pages=181–7 |date=2013 |pmid=24416992 |doi= |url=}}</ref><ref name="pmid15285297">{{cite journal |vauthors=Zanagnolo V, Pasinetti B, Sartori E |title=Clinical review of 63 cases of sex cord stromal tumors |journal=Eur. J. Gynaecol. Oncol. |volume=25 |issue=4 |pages=431–8 |date=2004 |pmid=15285297 |doi= |url=}}</ref> | *Depending on the extent of the [[tumor]] at the time of [[diagnosis]], the [[prognosis]] may vary. However, the [[prognosis]] is generally regarded as excellent<ref name="pmid16050568">{{cite journal |vauthors=Schneider DT, Calaminus G, Harms D, Göbel U |title=Ovarian sex cord-stromal tumors in children and adolescents |journal=J Reprod Med |volume=50 |issue=6 |pages=439–46 |date=June 2005 |pmid=16050568 |doi= |url=}}</ref><ref name="pmid24416992">{{cite journal |vauthors=Elashry R, Hemida R, Goda H, Abdel-Hady el-S |title=Prognostic factors of germ cell and sex cord-stromal ovarian tumors in pediatric age: 5 years experience |journal=J. Exp. Ther. Oncol. |volume=10 |issue=3 |pages=181–7 |date=2013 |pmid=24416992 |doi= |url=}}</ref><ref name="pmid15285297">{{cite journal |vauthors=Zanagnolo V, Pasinetti B, Sartori E |title=Clinical review of 63 cases of sex cord stromal tumors |journal=Eur. J. Gynaecol. Oncol. |volume=25 |issue=4 |pages=431–8 |date=2004 |pmid=15285297 |doi= |url=}}</ref><ref name="ZhangCheung2007">{{cite journal|last1=Zhang|first1=Mallory|last2=Cheung|first2=Michael K.|last3=Shin|first3=Jacob Y.|last4=Kapp|first4=Daniel S.|last5=Husain|first5=Amreen|last6=Teng|first6=Nelson N.|last7=Berek|first7=Jonathan S.|last8=Osann|first8=Kathryn|last9=Chan|first9=John K.|title=Prognostic factors responsible for survival in sex cord stromal tumors of the ovary—An analysis of 376 women|journal=Gynecologic Oncology|volume=104|issue=2|year=2007|pages=396–400|issn=00908258|doi=10.1016/j.ygyno.2006.08.032}}</ref><ref name="pmid24416992">{{cite journal |vauthors=Elashry R, Hemida R, Goda H, Abdel-Hady el-S |title=Prognostic factors of germ cell and sex cord-stromal ovarian tumors in pediatric age: 5 years experience |journal=J. Exp. Ther. Oncol. |volume=10 |issue=3 |pages=181–7 |date=2013 |pmid=24416992 |doi= |url=}}</ref><ref name="pmid29705285">{{cite journal |vauthors=Wang J, Li J, Chen R, Lu X |title=Contribution of lymph node staging method and prognostic factors in malignant ovarian sex cord-stromal tumors: A world wide database analysis |journal=Eur J Surg Oncol |volume=44 |issue=7 |pages=1054–1061 |date=July 2018 |pmid=29705285 |doi=10.1016/j.ejso.2018.03.027 |url=}}</ref> | ||
*The [[prognosis]] varies with the subtypes of [[tumor]] | |||
*Most sexcord-stromal ovarian tumors present at a low [[tumor]] [[Cancer staging|stage]] and also [[prognosis]] in these [[patients]] is excellent | |||
*The two important [[Predicate variable|predictors]] for improved [[Survival rate|survival]] in [[patients]] with [[ovarian]] sex cord stromal tumors are [[Young adult|young]] [[age]] and early-stage [[disease]] | |||
*[[Patients]] with juvinile [[granulosa cell tumors]](JGCT) and [[Sertoli-Leydig cell tumour|sertoli-Leydig cell tumors]] (SLCTs) show greater [[Mitotic index|mitotic]] activity than all other [[histologic]] types | |||
*The presence of greater [[mitotic]] activity is associated with a particularly poor [[prognosis]] among [[patients]] with juvinile [[granulosa cell tumors]](JGCT) and [[Sertoli-Leydig cell tumour|sertoli-Leydig cell tumors]] (SLCTs) | |||
*Other independent [[prognostic]] factors in adult [[granulosa cell tumors]] include [[mitotic index]], lymphovascular [[invasion]], [[cellular]] [[atypia]], and absence of [[Call-Exner bodies]] | |||
*Sertoli-Leydig cell tumors have a 70 to 90 percent five-year survival overall and is mainly related to the stage and degree of histologic differentiation | *[[Sertoli-Leydig cell tumour|Sertoli-Leydig cell tumors]] have a 70 to 90 percent five-year [[Survival rate|survival]] overall and is mainly related to the stage and degree of [[histologic]] [[differentiation]] | ||
==References== | ==References== | ||
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[[Category: | [[Category:Disease]] | ||
[[Category:Types of cancer]] | |||
[[Category:Gynecology]] | |||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | |||
[[Category:Medicine]] | |||
[[Category:Gynecology]] | |||
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Latest revision as of 00:56, 7 May 2019
Sexcord/ stromal ovarian tumors Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: ; Maneesha Nandimandalam, M.B.B.S.[2]
Overview
The symtoms of sexcord/ stromal ovarian tumors include Adnexal mass, Abdominal & pelvic symptoms, Bloating, Urinary urgency or frequency, Dysphagia(difficulty)eating) or feeling full quickly, Pelvic or abdominal pain. Common complications of sexcord/ stromal ovarian tumors include malignant pleural effusion,bowel obstruction,ascites. The prognosis varies with the subtypes of tumor. Most sexcord-stromal ovarian tumors present at a low tumor stage and also prognosis in these patients is excellent.
Natural History, Complications, and Prognosis
Natural History
- The symptoms of sexcord/ stromal ovarian tumors usually develop in the second/ third/ fourth decade of life, and start with symptoms such as:[1]
- Adnexal mass
- Abdominal & pelvic symptoms
- Bloating
- Urinary urgency or frequency
- Dysphagia(difficulty eating) or feeling full quickly
- Pelvic or abdominal pain
Complications
- Common complications of sexcord/ stromal ovarian tumors include:
Prognosis
- Depending on the extent of the tumor at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as excellent[2][3][4][5][3][6]
- The prognosis varies with the subtypes of tumor
- Most sexcord-stromal ovarian tumors present at a low tumor stage and also prognosis in these patients is excellent
- The two important predictors for improved survival in patients with ovarian sex cord stromal tumors are young age and early-stage disease
- Patients with juvinile granulosa cell tumors(JGCT) and sertoli-Leydig cell tumors (SLCTs) show greater mitotic activity than all other histologic types
- The presence of greater mitotic activity is associated with a particularly poor prognosis among patients with juvinile granulosa cell tumors(JGCT) and sertoli-Leydig cell tumors (SLCTs)
- Other independent prognostic factors in adult granulosa cell tumors include mitotic index, lymphovascular invasion, cellular atypia, and absence of Call-Exner bodies
- Sertoli-Leydig cell tumors have a 70 to 90 percent five-year survival overall and is mainly related to the stage and degree of histologic differentiation
References
- ↑ Ayhan A, Salman MC, Velipasaoglu M, Sakinci M, Yuce K (September 2009). "Prognostic factors in adult granulosa cell tumors of the ovary: a retrospective analysis of 80 cases". J Gynecol Oncol. 20 (3): 158–63. doi:10.3802/jgo.2009.20.3.158. PMID 19809549.
- ↑ Schneider DT, Calaminus G, Harms D, Göbel U (June 2005). "Ovarian sex cord-stromal tumors in children and adolescents". J Reprod Med. 50 (6): 439–46. PMID 16050568.
- ↑ 3.0 3.1 Elashry R, Hemida R, Goda H, Abdel-Hady e (2013). "Prognostic factors of germ cell and sex cord-stromal ovarian tumors in pediatric age: 5 years experience". J. Exp. Ther. Oncol. 10 (3): 181–7. PMID 24416992. Vancouver style error: initials (help)
- ↑ Zanagnolo V, Pasinetti B, Sartori E (2004). "Clinical review of 63 cases of sex cord stromal tumors". Eur. J. Gynaecol. Oncol. 25 (4): 431–8. PMID 15285297.
- ↑ Zhang, Mallory; Cheung, Michael K.; Shin, Jacob Y.; Kapp, Daniel S.; Husain, Amreen; Teng, Nelson N.; Berek, Jonathan S.; Osann, Kathryn; Chan, John K. (2007). "Prognostic factors responsible for survival in sex cord stromal tumors of the ovary—An analysis of 376 women". Gynecologic Oncology. 104 (2): 396–400. doi:10.1016/j.ygyno.2006.08.032. ISSN 0090-8258.
- ↑ Wang J, Li J, Chen R, Lu X (July 2018). "Contribution of lymph node staging method and prognostic factors in malignant ovarian sex cord-stromal tumors: A world wide database analysis". Eur J Surg Oncol. 44 (7): 1054–1061. doi:10.1016/j.ejso.2018.03.027. PMID 29705285.