Acute promyelocytic leukemia history and symptoms: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Acute promyelocytic leukemia}} | {{Acute promyelocytic leukemia}} | ||
{{CMG}} {{shyam}} | {{CMG}}; {{AE}} {{shyam}}, {{S.G.}}; {{GRR}} {{Nat}} | ||
==Overview== | ==Overview== | ||
[[Medical sign|Signs]] and [[Symptom|symptoms]] of acute promyelocytic leukemia are similar to other forms of [[leukemia]], but [[bleeding]] and [[hemorrhagic]] events are more specific for acute promyelocytic leukemia since these | [[Medical sign|Signs]] and [[Symptom|symptoms]] of acute promyelocytic leukemia are similar to other forms of [[leukemia]], but [[bleeding]] and [[hemorrhagic]] events are more specific for acute promyelocytic leukemia since these patients are more likely to present with [[disseminated intravascular coagulation]] ([[coagulopathy]]). | ||
==Symptoms== | ==Symptoms== | ||
Patients with acute promyelocytic leukemia present with a variety of symptoms. The symptoms are related to decreased production of normal [[red blood cells]], [[white blood cells]], and [[Platelet|platelets]].<ref name="pmid21645417">{{cite journal| author=Hu R, Wu Y, Jiang X, Zhang W, Xu L| title=Clinical symptoms and chemotherapy completion in elderly patients with newly diagnosed acute leukemia: a retrospective comparison study with a younger cohort. | journal=BMC Cancer | year= 2011 | volume= 11 | issue= | pages= 224 | pmid=21645417 | doi=10.1186/1471-2407-11-224 | pmc=3130702 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21645417 }} </ref> | |||
Patients with acute promyelocytic leukemia have an excess number of [[Blast|blasts]] in the [[bone marrow]], and this results in [[myelophthisis]], or crowding out of the normal [[hematopoietic]] cells, which accounts for the symptoms.<ref name="EfficaceBreccia20182">{{cite journal|last1=Efficace|first1=Fabio|last2=Breccia|first2=Massimo|last3=Avvisati|first3=Giuseppe|last4=Cottone|first4=Francesco|last5=Intermesoli|first5=Tamara|last6=Borlenghi|first6=Erika|last7=Carluccio|first7=Paola|last8=Rodeghiero|first8=Francesco|last9=Fabbiano|first9=Francesco|last10=Luppi|first10=Mario|last11=Romani|first11=Claudio|last12=Sborgia|first12=Marco|last13=D’Ardia|first13=Stefano|last14=Nobile|first14=Francesco|last15=Cantore|first15=Nicola|last16=Crugnola|first16=Monica|last17=Nadali|first17=Gianpaolo|last18=Vignetti|first18=Marco|last19=Amadori|first19=Sergio|last20=Lo Coco|first20=Francesco|title=Health-related quality of life, symptom burden, and comorbidity in long-term survivors of acute promyelocytic leukemia|journal=Leukemia|year=2018|issn=0887-6924|doi=10.1038/s41375-018-0325-4}}</ref><ref name="pmid27400009">{{cite journal |vauthors=Nebgen DR, Rhodes HE, Hartman C, Munsell MF, Lu KH |title=Abnormal Uterine Bleeding as the Presenting Symptom of Hematologic Cancer |journal=Obstet Gynecol |volume=128 |issue=2 |pages=357–63 |date=August 2016 |pmid=27400009 |pmc=4961605 |doi=10.1097/AOG.0000000000001529 |url=}}</ref> | |||
*[[Fever]] | *[[Fever]] | ||
*[[Fatigue]] | *[[Fatigue]] | ||
Latest revision as of 13:11, 11 April 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shyam Patel [2], Sogand Goudarzi, MD [3]; Grammar Reviewer: Natalie Harpenau, B.S.[4]
Overview
Signs and symptoms of acute promyelocytic leukemia are similar to other forms of leukemia, but bleeding and hemorrhagic events are more specific for acute promyelocytic leukemia since these patients are more likely to present with disseminated intravascular coagulation (coagulopathy).
Symptoms
Patients with acute promyelocytic leukemia present with a variety of symptoms. The symptoms are related to decreased production of normal red blood cells, white blood cells, and platelets.[1]
Patients with acute promyelocytic leukemia have an excess number of blasts in the bone marrow, and this results in myelophthisis, or crowding out of the normal hematopoietic cells, which accounts for the symptoms.[2][3]
- Fever
- Fatigue
- Weight loss
- Loss of appetite
- Shortness of breath with exertion
- Easy bruising from thrombocytopenia and coagulopathy
- Mucosal bleeding from thrombocytopenia and coagulopathy
- Bone and joint pain
- Leg swelling
- Dizziness
- Persistent or frequent infections (from lack of normal white blood cells)
References
- ↑ Hu R, Wu Y, Jiang X, Zhang W, Xu L (2011). "Clinical symptoms and chemotherapy completion in elderly patients with newly diagnosed acute leukemia: a retrospective comparison study with a younger cohort". BMC Cancer. 11: 224. doi:10.1186/1471-2407-11-224. PMC 3130702. PMID 21645417.
- ↑ Efficace, Fabio; Breccia, Massimo; Avvisati, Giuseppe; Cottone, Francesco; Intermesoli, Tamara; Borlenghi, Erika; Carluccio, Paola; Rodeghiero, Francesco; Fabbiano, Francesco; Luppi, Mario; Romani, Claudio; Sborgia, Marco; D’Ardia, Stefano; Nobile, Francesco; Cantore, Nicola; Crugnola, Monica; Nadali, Gianpaolo; Vignetti, Marco; Amadori, Sergio; Lo Coco, Francesco (2018). "Health-related quality of life, symptom burden, and comorbidity in long-term survivors of acute promyelocytic leukemia". Leukemia. doi:10.1038/s41375-018-0325-4. ISSN 0887-6924.
- ↑ Nebgen DR, Rhodes HE, Hartman C, Munsell MF, Lu KH (August 2016). "Abnormal Uterine Bleeding as the Presenting Symptom of Hematologic Cancer". Obstet Gynecol. 128 (2): 357–63. doi:10.1097/AOG.0000000000001529. PMC 4961605. PMID 27400009.