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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''ADP-ribosylation factor-like protein 2''' is a [[protein]] that in humans is encoded by the ''ARL2'' [[gene]].<ref name="pmid8415637">{{cite journal | vauthors = Clark J, Moore L, Krasinskas A, Way J, Battey J, Tamkun J, Kahn RA | title = Selective amplification of additional members of the ADP-ribosylation factor (ARF) family: cloning of additional human and Drosophila ARF-like genes | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 90 | issue = 19 | pages = 8952–6  | date = November 1993 | pmid = 8415637 | pmc = 47479 | doi = 10.1073/pnas.90.19.8952 }}</ref><ref name="pmid9253601">{{cite journal | vauthors = Guru SC, Agarwal SK, Manickam P, Olufemi SE, Crabtree JS, Weisemann JM, Kester MB, Kim YS, Wang Y, Emmert-Buck MR, Liotta LA, Spiegel AM, Boguski MS, Roe BA, Collins FS, Marx SJ, Burns L, Chandrasekharappa SC | title = A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus | journal = Genome Res. | volume = 7 | issue = 7 | pages = 725–35  | date = September 1997 | pmid = 9253601 | pmc = 310681 | doi = 10.1101/gr.7.7.725 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ARL2 ADP-ribosylation factor-like 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=402| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_ARL2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ksg.
| PDB = {{PDB2|1ksg}}, {{PDB2|1ksh}}, {{PDB2|1ksj}}
| Name = ADP-ribosylation factor-like 2
| HGNCid = 693
| Symbol = ARL2
| AltSymbols =; ARFL2
| OMIM = 601175
| ECnumber = 
| Homologene = 1260
| MGIid = 1928393
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005095 |text = GTPase inhibitor activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0007021 |text = tubulin folding}} {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 402
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_001658
    | Hs_RefseqmRNA = NM_001667
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 56327
    | Mm_Ensembl = ENSMUSG00000024944
    | Mm_RefseqmRNA = NM_019722
    | Mm_RefseqProtein = NP_062696
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 6134387
    | Mm_GenLoc_end = 6141140
    | Mm_Uniprot = Q9D0J4
  }}
}}
'''ADP-ribosylation factor-like 2''', also known as '''ARL2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ARL2 ADP-ribosylation factor-like 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=402| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The ADP-ribosylation factor (ARF) genes are small GTP-binding proteins of the RAS superfamily.  ARL2 is a member of a functionally distinct group of ARF-like genes.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The ADP-ribosylation factor (ARF) genes are small GTP-binding proteins of the RAS superfamily.  ARL2 is a member of a functionally distinct group of ARF-like genes.<ref name="entrez">{{cite web | title = Entrez Gene: ARL2 ADP-ribosylation factor-like 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=402| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
ARL2 has been shown to [[Protein-protein interaction|interact]] with [[Protein unc-119 homolog]],<ref name=pmid12527357>{{cite journal | vauthors = Kobayashi A, Kubota S, Mori N, McLaren MJ, Inana G | title = Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain | journal = FEBS Lett. | volume = 534 | issue = 1-3 | pages = 26–32  | date = January 2003 | pmid = 12527357 | doi = 10.1016/S0014-5793(02)03766-3 }}</ref> [[TBCD]]<ref name=pmid12912990>{{cite journal | vauthors = Shern JF, Sharer JD, Pallas DC, Bartolini F, Cowan NJ, Reed MS, Pohl J, Kahn RA | title = Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A | journal = J. Biol. Chem. | volume = 278 | issue = 42 | pages = 40829–36  | date = October 2003 | pmid = 12912990 | doi = 10.1074/jbc.M308678200 }}</ref><ref name=pmid10831612>{{cite journal | vauthors = Bhamidipati A, Lewis SA, Cowan NJ | title = ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin | journal = J. Cell Biol. | volume = 149 | issue = 5 | pages = 1087–96  | date = May 2000 | pmid = 10831612 | pmc = 2174823 | doi = 10.1083/jcb.149.5.1087 }}</ref> and [[PDE6D]].<ref name=pmid16189514>{{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8  | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref><ref name=pmid11980706>{{cite journal | vauthors = Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC | title = The complex of Arl2-GTP and PDE delta: from structure to function | journal = EMBO J. | volume = 21 | issue = 9 | pages = 2095–106  | date = May 2002 | pmid = 11980706 | pmc = 125981 | doi = 10.1093/emboj/21.9.2095 }}</ref>
 
== References ==
{{reflist}}
{{Clear}}
 
==External links==
* {{UCSC gene info|ARL2}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Bhamidipati A, Lewis SA, Cowan NJ | title = ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin | journal = J. Cell Biol. | volume = 149 | issue = 5 | pages = 1087–96 | year = 2000 | pmid = 10831612 | pmc = 2174823 | doi = 10.1083/jcb.149.5.1087 }}
*{{cite journal  | author=Clark J, Moore L, Krasinskas A, ''et al.'' |title=Selective amplification of additional members of the ADP-ribosylation factor (ARF) family: cloning of additional human and Drosophila ARF-like genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 19 |pages= 8952-6 |year= 1993 |pmid= 8415637 |doi=  }}
* {{cite journal | vauthors = Sharer JD, Shern JF, Van Valkenburgh H, Wallace DC, Kahn RA | title = ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter | journal = Mol. Biol. Cell | volume = 13 | issue = 1 | pages = 71–83 | year = 2002 | pmid = 11809823 | pmc = 65073 | doi = 10.1091/mbc.01-05-0245 }}
*{{cite journal  | author=Guru SC, Agarwal SK, Manickam P, ''et al.'' |title=A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. |journal=Genome Res. |volume=7 |issue= 7 |pages= 725-35 |year= 1997 |pmid= 9253601 |doi=  }}
* {{cite journal | vauthors = Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC | title = The complex of Arl2-GTP and PDE delta: from structure to function | journal = EMBO J. | volume = 21 | issue = 9 | pages = 2095–106 | year = 2002 | pmid = 11980706 | pmc = 125981 | doi = 10.1093/emboj/21.9.2095 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Antoshechkin I, Han M | title = The C. elegans evl-20 gene is a homolog of the small GTPase ARL2 and regulates cytoskeleton dynamics during cytokinesis and morphogenesis | journal = Dev. Cell | volume = 2 | issue = 5 | pages = 579–91 | year = 2002 | pmid = 12015966 | doi = 10.1016/S1534-5807(02)00146-6 }}
*{{cite journal | author=Bhamidipati A, Lewis SA, Cowan NJ |title=ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin. |journal=J. Cell Biol. |volume=149 |issue= 5 |pages= 1087-96 |year= 2000 |pmid= 10831612 |doi= }}
* {{cite journal | vauthors = Kobayashi A, Kubota S, Mori N, McLaren MJ, Inana G | title = Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain | journal = FEBS Lett. | volume = 534 | issue = 1-3 | pages = 26–32 | year = 2003 | pmid = 12527357 | doi = 10.1016/S0014-5793(02)03766-3 }}
*{{cite journal | author=Sharer JD, Shern JF, Van Valkenburgh H, ''et al.'' |title=ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter. |journal=Mol. Biol. Cell |volume=13 |issue= 1 |pages= 71-83 |year= 2002 |pmid= 11809823 |doi= 10.1091/mbc.01-05-0245 }}
* {{cite journal | vauthors = Shern JF, Sharer JD, Pallas DC, Bartolini F, Cowan NJ, Reed MS, Pohl J, Kahn RA | title = Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A | journal = J. Biol. Chem. | volume = 278 | issue = 42 | pages = 40829–36 | year = 2003 | pmid = 12912990 | doi = 10.1074/jbc.M308678200 }}
*{{cite journal | author=Hanzal-Bayer M, Renault L, Roversi P, ''et al.'' |title=The complex of Arl2-GTP and PDE delta: from structure to function. |journal=EMBO J. |volume=21 |issue= 9 |pages= 2095-106 |year= 2002 |pmid= 11980706 |doi= 10.1093/emboj/21.9.2095 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Antoshechkin I, Han M |title=The C. elegans evl-20 gene is a homolog of the small GTPase ARL2 and regulates cytoskeleton dynamics during cytokinesis and morphogenesis. |journal=Dev. Cell |volume=2 |issue= 5 |pages= 579-91 |year= 2002 |pmid= 12015966 |doi= }}
* {{cite journal | vauthors = Zhou C, Cunningham L, Marcus AI, Li Y, Kahn RA | title = Arl2 and Arl3 regulate different microtubule-dependent processes | journal = Mol. Biol. Cell | volume = 17 | issue = 5 | pages = 2476–87 | year = 2006 | pmid = 16525022 | pmc = 1446103 | doi = 10.1091/mbc.E05-10-0929 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Beghin A, Honore S, Messana C, Matera EL, Aim J, Burlinchon S, Braguer D, Dumontet C | title = ADP ribosylation factor like 2 (Arl2) protein influences microtubule dynamics in breast cancer cells | journal = Exp. Cell Res. | volume = 313 | issue = 3 | pages = 473–85 | year = 2007 | pmid = 17188265 | doi = 10.1016/j.yexcr.2006.10.024 }}
*{{cite journal | author=Kobayashi A, Kubota S, Mori N, ''et al.'' |title=Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain. |journal=FEBS Lett. |volume=534 |issue= 1-3 |pages= 26-32 |year= 2004 |pmid= 12527357 |doi= }}
*{{cite journal | author=Shern JF, Sharer JD, Pallas DC, ''et al.'' |title=Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A. |journal=J. Biol. Chem. |volume=278 |issue= 42 |pages= 40829-36 |year= 2003 |pmid= 12912990 |doi= 10.1074/jbc.M308678200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Zhou C, Cunningham L, Marcus AI, ''et al.'' |title=Arl2 and Arl3 regulate different microtubule-dependent processes. |journal=Mol. Biol. Cell |volume=17 |issue= 5 |pages= 2476-87 |year= 2006 |pmid= 16525022 |doi= 10.1091/mbc.E05-10-0929 }}
*{{cite journal | author=Beghin A, Honore S, Messana C, ''et al.'' |title=ADP ribosylation factor like 2 (Arl2) protein influences microtubule dynamics in breast cancer cells. |journal=Exp. Cell Res. |volume=313 |issue= 3 |pages= 473-85 |year= 2007 |pmid= 17188265 |doi= 10.1016/j.yexcr.2006.10.024 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=402}}


{{protein-stub}}
{{protein-stub}}
{{WikiDoc Sources}}

Latest revision as of 15:40, 8 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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n/a

Ensembl

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UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

ADP-ribosylation factor-like protein 2 is a protein that in humans is encoded by the ARL2 gene.[1][2][3]

Function

The ADP-ribosylation factor (ARF) genes are small GTP-binding proteins of the RAS superfamily. ARL2 is a member of a functionally distinct group of ARF-like genes.[3]

Interactions

ARL2 has been shown to interact with Protein unc-119 homolog,[4] TBCD[5][6] and PDE6D.[7][8]

References

  1. ↑ Clark J, Moore L, Krasinskas A, Way J, Battey J, Tamkun J, Kahn RA (November 1993). "Selective amplification of additional members of the ADP-ribosylation factor (ARF) family: cloning of additional human and Drosophila ARF-like genes". Proc. Natl. Acad. Sci. U.S.A. 90 (19): 8952–6. doi:10.1073/pnas.90.19.8952. PMC 47479. PMID 8415637.
  2. ↑ Guru SC, Agarwal SK, Manickam P, Olufemi SE, Crabtree JS, Weisemann JM, Kester MB, Kim YS, Wang Y, Emmert-Buck MR, Liotta LA, Spiegel AM, Boguski MS, Roe BA, Collins FS, Marx SJ, Burns L, Chandrasekharappa SC (September 1997). "A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus". Genome Res. 7 (7): 725–35. doi:10.1101/gr.7.7.725. PMC 310681. PMID 9253601.
  3. ↑ 3.0 3.1 "Entrez Gene: ARL2 ADP-ribosylation factor-like 2".
  4. ↑ Kobayashi A, Kubota S, Mori N, McLaren MJ, Inana G (January 2003). "Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain". FEBS Lett. 534 (1–3): 26–32. doi:10.1016/S0014-5793(02)03766-3. PMID 12527357.
  5. ↑ Shern JF, Sharer JD, Pallas DC, Bartolini F, Cowan NJ, Reed MS, Pohl J, Kahn RA (October 2003). "Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A". J. Biol. Chem. 278 (42): 40829–36. doi:10.1074/jbc.M308678200. PMID 12912990.
  6. ↑ Bhamidipati A, Lewis SA, Cowan NJ (May 2000). "ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin". J. Cell Biol. 149 (5): 1087–96. doi:10.1083/jcb.149.5.1087. PMC 2174823. PMID 10831612.
  7. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  8. ↑ Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC (May 2002). "The complex of Arl2-GTP and PDE delta: from structure to function". EMBO J. 21 (9): 2095–106. doi:10.1093/emboj/21.9.2095. PMC 125981. PMID 11980706.

External links

Further reading


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