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==Overview==
 
==Laboratory Findings==
The diagnosis of alpha-1 AT deficiency should be suspected in any patient who:
# Develops [[emphysema]] younger than 45 years old, if they are a non/minimal smoker, or if they have primarily basilar disease OR
# Has a history of [[panniculitis]] or
# Has or has a family history of unexplained liver disease (especially [[cirrhosis]] or [[hepatoma]]). <br>
 
* In suspected individuals the initial step is to measure the serum alpha-1 AT concentration.
* In general, phenotyping should be reserved for patients who have low or borderline low alpha-1 AT levels.  
* PFTs-pulmonary function tests (spirometry pre and post bronchodilators, lung volumes and diffusing capacity),
* LFTs (liver function test)
* ABG-arterial blood gases (usually)


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}


[[Category:Needs content]]
[[Category:Gastroenterology]]
[[Category:Pulmonology]]
[[Category:Hepatology]]


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Latest revision as of 15:26, 1 June 2016

Alpha 1-antitrypsin deficiency Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:

Overview

Laboratory Findings

The diagnosis of alpha-1 AT deficiency should be suspected in any patient who:

  1. Develops emphysema younger than 45 years old, if they are a non/minimal smoker, or if they have primarily basilar disease OR
  2. Has a history of panniculitis or
  3. Has or has a family history of unexplained liver disease (especially cirrhosis or hepatoma).
  • In suspected individuals the initial step is to measure the serum alpha-1 AT concentration.
  • In general, phenotyping should be reserved for patients who have low or borderline low alpha-1 AT levels.
  • PFTs-pulmonary function tests (spirometry pre and post bronchodilators, lung volumes and diffusing capacity),
  • LFTs (liver function test)
  • ABG-arterial blood gases (usually)

References


Template:WikiDoc Sources