Alpha 1-antitrypsin deficiency risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mazia Fatima, MBBS [2]
Overview
First degree relatives of patients with known AAT deficiency are at an increased risk for the condition. Smoking is risk factor for development of serious lung disease in patients with AAT deficiency. Risk for lung disease also increases with exposure to dust, fumes, or other toxic substances.
Risk Factors
Risk factors associated with development of alpha 1-antitrypsin deficiency are as follows:[1][2]
- First degree relatives of patients with known AAT deficiency are at an increased risk of inheriting the disorder.
- Smoking is risk factor for development of serious lung disease in patients with AAT deficiency.
- Risk for lung disease also increases with exposure to dust, fumes, or other toxic substances.
References
- ↑ Kalfopoulos M, Wetmore K, ElMallah MK (2017). "Pathophysiology of Alpha-1 Antitrypsin Lung Disease". Methods Mol. Biol. 1639: 9–19. doi:10.1007/978-1-4939-7163-3_2. PMID 28752442.
- ↑ Stoller JK, Aboussouan LS (2012). "A review of α1-antitrypsin deficiency". Am. J. Respir. Crit. Care Med. 185 (3): 246–59. doi:10.1164/rccm.201108-1428CI. PMID 21960536.