Hypoalbuminemia: Difference between revisions
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{{SK}} low albumin; low serum albumin; reduced albumin; hypoalbuminism; | |||
==Overview== | |||
'''Hypoalbuminemia''' is a medical condition where levels of [[human serum albumin|albumin]] in [[blood serum]] are abnormally low. It is a specific form of [[hypoproteinemia]]. | '''Hypoalbuminemia''' is a medical condition where levels of [[human serum albumin|albumin]] in [[blood serum]] are abnormally low. It is a specific form of [[hypoproteinemia]]. | ||
Albumin is a major protein in the human body, making up about 60% of total human [[Blood plasma|plasma]] protein by mass. Many [[hormone]]s, [[drug]]s, and other molecules are mostly bound to albumin in the bloodstream and must be released before becoming biologically active. | ==Pathophysiology== | ||
[[Albumin]] is a major protein in the human body, making up about 60% of total human [[Blood plasma|plasma]] protein by mass. Many [[hormone]]s, [[drug]]s, and other molecules are mostly bound to albumin in the bloodstream and must be released before becoming biologically active. | |||
Albumin is synthesized in the [[liver]], and low serum albumin may be indicative of [[liver failure]] or diseases such as [[cirrhosis]] or chronic [[hepatitis]]. Hypoalbuminemia can also present as part of the [[nephrotic syndrome]], in which protein is lost in the [[urine]] due to [[kidney]] damage. Low albumin levels can be an indicator of chronic [[malnutrition]]. | Albumin is synthesized in the [[liver]], and low serum albumin may be indicative of [[liver failure]] or diseases such as [[cirrhosis]] or chronic [[hepatitis]]. Hypoalbuminemia can also present as part of the [[nephrotic syndrome]], in which protein is lost in the [[urine]] due to [[kidney]] damage. Low albumin levels can be an indicator of chronic [[malnutrition]]. | ||
==Causes== | |||
===Causes in Alphabetical Order=== | |||
*[[Acute phase reaction]] | |||
*[[Analbuminaemia]] | |||
*[[Cirrhosis]] | |||
*[[Hepatitis]] | |||
*[[Liver failure]] | |||
*[[Malnutrition]] | |||
*Drug Side Effect- [[Cefpodoxime]],[[Denileukin diftitox]] [[Ibuprofen]],[[Dapsone]], [[Streptozocin]] | |||
*[[Nephrotic syndrome]] | |||
*[[Sorafenib]] | |||
*[[Protein losing enteropathy]] | |||
*[[Starvation]] | |||
==Diagnosis== | |||
===Symptoms=== | |||
*[[Generalized edema]] (swelling) via a decrease in [[oncotic pressure]]. | |||
===Physical Examination=== | |||
*[[Generalized edema]] (swelling) via a decrease in [[oncotic pressure]]. | |||
===Laboratory Findings=== | |||
The serum albumin level is part of a standard panel of [[liver function tests]]. Levels below 3.5 grams per deciliter are generally considered low. | The serum albumin level is part of a standard panel of [[liver function tests]]. Levels below 3.5 grams per deciliter are generally considered low. | ||
{{WH}} | {{WH}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
[[pl:Hipoalbuminemia]] | [[pl:Hipoalbuminemia]] | ||
[[pt:Hipoalbuminemia]] | [[pt:Hipoalbuminemia]] | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Intensive care medicine]] | |||
Latest revision as of 20:00, 8 June 2015
Template:DiseaseDisorder infobox
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords: low albumin; low serum albumin; reduced albumin; hypoalbuminism;
Overview
Hypoalbuminemia is a medical condition where levels of albumin in blood serum are abnormally low. It is a specific form of hypoproteinemia.
Pathophysiology
Albumin is a major protein in the human body, making up about 60% of total human plasma protein by mass. Many hormones, drugs, and other molecules are mostly bound to albumin in the bloodstream and must be released before becoming biologically active.
Albumin is synthesized in the liver, and low serum albumin may be indicative of liver failure or diseases such as cirrhosis or chronic hepatitis. Hypoalbuminemia can also present as part of the nephrotic syndrome, in which protein is lost in the urine due to kidney damage. Low albumin levels can be an indicator of chronic malnutrition.
Causes
Causes in Alphabetical Order
- Acute phase reaction
- Analbuminaemia
- Cirrhosis
- Hepatitis
- Liver failure
- Malnutrition
- Drug Side Effect- Cefpodoxime,Denileukin diftitox Ibuprofen,Dapsone, Streptozocin
- Nephrotic syndrome
- Sorafenib
- Protein losing enteropathy
- Starvation
Diagnosis
Symptoms
- Generalized edema (swelling) via a decrease in oncotic pressure.
Physical Examination
- Generalized edema (swelling) via a decrease in oncotic pressure.
Laboratory Findings
The serum albumin level is part of a standard panel of liver function tests. Levels below 3.5 grams per deciliter are generally considered low.