Non-alcoholic fatty liver disease other imaging findings: Difference between revisions
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There are no other imaging findings associated with non-alcoholic fatty liver disease. | There are no other imaging findings associated with non-alcoholic fatty liver disease. | ||
==Liver stiffness measurement (LSM) == | ==Liver stiffness measurement (LSM) by elastography == | ||
Two-dimensional shear wave elastography [SWE]) can estimate liver stiffness measurements: "LS of 8 and 12.5 kPa represent generally accepted cut-off values for F3 and F4 fibrosis. LS highly correlates with portal pressure, and esophageal varices are likely at values >20 kPa."<ref name="pmid24367208">{{cite journal| author=Mueller S, Sandrin L| title=Liver stiffness: a novel parameter for the diagnosis of liver disease. | journal=Hepat Med | year= 2010 | volume= 2 | issue= | pages= 49-67 | pmid=24367208 | doi=10.2147/hmer.s7394 | pmc=3846375 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24367208 }} </ref> | |||
* LS of 8 suggests F3 fibrosis | * LS of 8 suggests F3 fibrosis | ||
* LS of 12.5 kPa suggests F4 fibrosis | * LS of 12.5 kPa suggests F4 fibrosis | ||
The FibroScan can measure LSM | A more recent study suggests lower cutoffs<ref name="pmid30689971">{{cite journal| author=Eddowes PJ, Sasso M, Allison M, Tsochatzis E, Anstee QM, Sheridan D | display-authors=etal| title=Accuracy of FibroScan Controlled Attenuation Parameter and Liver Stiffness Measurement in Assessing Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease. | journal=Gastroenterology | year= 2019 | volume= 156 | issue= 6 | pages= 1717-1730 | pmid=30689971 | doi=10.1053/j.gastro.2019.01.042 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30689971 }} </ref>: | ||
* LS of 6 suggests F2 fibrosis | |||
* LS of 7 suggests F3 fibrosis | |||
* LS of 11 kPa suggests F4 fibrosis | |||
The FibroScan can measure LSM by SWE | |||
== Magnetic resonance elastography == | |||
Magnetic resonance elastography (MRE) may be more accurate than elastography<ref name="pmid25305349">{{cite journal| author=Singh S, Venkatesh SK, Wang Z, Miller FH, Motosugi U, Low RN | display-authors=etal| title=Diagnostic performance of magnetic resonance elastography in staging liver fibrosis: a systematic review and meta-analysis of individual participant data. | journal=Clin Gastroenterol Hepatol | year= 2015 | volume= 13 | issue= 3 | pages= 440-451.e6 | pmid=25305349 | doi=10.1016/j.cgh.2014.09.046 | pmc=4333001 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25305349 }} </ref> | |||
==Hepatic steatosis== | |||
Hepattic steatosis can be measured with the Controlled attenuation parameter (CAP).<ref name="pmid33460567">{{cite journal| author=Petroff D, Blank V, Newsome PN, Voican CS, Thiele M | display-authors=etal| title=Assessment of hepatic steatosis by controlled attenuation parameter using the M and XL probes: an individual patient data meta-analysis. | journal=Lancet Gastroenterol Hepatol | year= 2021 | volume= 6 | issue= 3 | pages= 185-198 | pmid=33460567 | doi=10.1016/S2468-1253(20)30357-5 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=33460567 }} </ref><ref name="pmid30689971">{{cite journal| author=Eddowes PJ, Sasso M, Allison M, Tsochatzis E, Anstee QM, Sheridan D | display-authors=etal| title=Accuracy of FibroScan Controlled Attenuation Parameter and Liver Stiffness Measurement in Assessing Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease. | journal=Gastroenterology | year= 2019 | volume= 156 | issue= 6 | pages= 1717-1730 | pmid=30689971 | doi=10.1053/j.gastro.2019.01.042 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30689971 }} </ref> | |||
==Other imaging== | ==Other imaging== | ||
Latest revision as of 00:42, 2 July 2024
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
There are no other imaging findings associated with non-alcoholic fatty liver disease.
Liver stiffness measurement (LSM) by elastography
Two-dimensional shear wave elastography [SWE]) can estimate liver stiffness measurements: "LS of 8 and 12.5 kPa represent generally accepted cut-off values for F3 and F4 fibrosis. LS highly correlates with portal pressure, and esophageal varices are likely at values >20 kPa."[1]
- LS of 8 suggests F3 fibrosis
- LS of 12.5 kPa suggests F4 fibrosis
A more recent study suggests lower cutoffs[2]:
- LS of 6 suggests F2 fibrosis
- LS of 7 suggests F3 fibrosis
- LS of 11 kPa suggests F4 fibrosis
The FibroScan can measure LSM by SWE
Magnetic resonance elastography
Magnetic resonance elastography (MRE) may be more accurate than elastography[3]
Hepatic steatosis
Hepattic steatosis can be measured with the Controlled attenuation parameter (CAP).[4][2]
Other imaging
CT scan: "≤ 40 Hounsfield units indicating > 30% hepatic steatosis"[5].
References
- ↑ Mueller S, Sandrin L (2010). "Liver stiffness: a novel parameter for the diagnosis of liver disease". Hepat Med. 2: 49–67. doi:10.2147/hmer.s7394. PMC 3846375. PMID 24367208.
- ↑ 2.0 2.1 Eddowes PJ, Sasso M, Allison M, Tsochatzis E, Anstee QM, Sheridan D; et al. (2019). "Accuracy of FibroScan Controlled Attenuation Parameter and Liver Stiffness Measurement in Assessing Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease". Gastroenterology. 156 (6): 1717–1730. doi:10.1053/j.gastro.2019.01.042. PMID 30689971.
- ↑ Singh S, Venkatesh SK, Wang Z, Miller FH, Motosugi U, Low RN; et al. (2015). "Diagnostic performance of magnetic resonance elastography in staging liver fibrosis: a systematic review and meta-analysis of individual participant data". Clin Gastroenterol Hepatol. 13 (3): 440–451.e6. doi:10.1016/j.cgh.2014.09.046. PMC 4333001. PMID 25305349.
- ↑ Petroff D, Blank V, Newsome PN, Voican CS, Thiele M; et al. (2021). "Assessment of hepatic steatosis by controlled attenuation parameter using the M and XL probes: an individual patient data meta-analysis". Lancet Gastroenterol Hepatol. 6 (3): 185–198. doi:10.1016/S2468-1253(20)30357-5. PMID 33460567 Check
|pmid=value (help). - ↑