Zolpidem overdose
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overdosage topics
Signs and symptoms
Recommended treatment
Signs and symptoms
In postmarketing experience of overdose with Zolpidem alone, or in combination with CNS-depressant agents, impairment of consciousness ranging from somnolence to coma, cardiovascular and/or respiratory compromise, and fatal outcomes have been reported. Return to top
Recommended treatment
General symptomatic and supportive measures should be used along with immediate gastric lavage where appropriate. Intravenous fluids should be administered as needed.
Flumazenil may be useful; however, flumazenil administration may contribute to the appearance of neurological symptoms (convulsions). As in all cases of drug overdose, respiration, pulse, blood pressure, and other appropriate signs should be monitored and general supportive measures employed. Return to top
Hypotension and CNS depression
Hypotension and CNS depression should be monitored and treated by appropriate medical intervention. Return to top
Sedatives
Sedating drugs should be withheld following Zolpidem overdosage, even if excitation occurs. Return to top
Dialysis
The value of dialysis in the treatment of overdosage has not been determined, although hemodialysis studies in patients with renal failure receiving therapeutic doses have demonstrated that Zolpidem is not dialyzable.
As with the management of all overdosage, the possibility of multiple drug ingestion should be considered. The physician may wish to consider contacting a poison control center for up-to-date information on the management of hypnotic drug product overdosage. Return to top
Adapted from the FDA Package Insert.