The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 99% and 91% amino acid identity to the mouse and Xenopus Wnt7A proteins, respectively. Among members of the human WNT family, this protein is most similar to WNT7A protein (77.1% total amino acid identity). This gene may play important roles in the development and progression of gastric cancer, esophageal cancer, and pancreatic cancer.[4]
References
↑Huguet EL, McMahon JA, McMahon AP, Bicknell R, Harris AL (Jun 1994). "Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue". Cancer Res. 54 (10): 2615–21. PMID8168088.
↑van Bokhoven H, Kissing J, Schepens M, van Beersum S, Simons A, Riegman P, McMahon JA, McMahon AP, Brunner HG (Sep 1997). "Assignment of WNT7B to human chromosome band 22q13 by in situ hybridization". Cytogenet Cell Genet. 77 (3–4): 288–9. doi:10.1159/000134600. PMID9284940.
↑Kirikoshi H, Sekihara H, Katoh M (Sep 2001). "Molecular cloning and characterization of human WNT7B". Int J Oncol. 19 (4): 779–83. doi:10.3892/ijo.19.4.779. PMID11562755.
Tanaka K, Okabayashi K, Asashima M, et al. (2000). "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family". Eur. J. Biochem. 267 (13): 4300–11. doi:10.1046/j.1432-1033.2000.01478.x. PMID10866835.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Capurro MI, Shi W, Sandal S, Filmus J (2006). "Processing by convertases is not required for glypican-3-induced stimulation of hepatocellular carcinoma growth". J. Biol. Chem. 280 (50): 41201–6. doi:10.1074/jbc.M507004200. PMID16227623.
