Vanishing twin

Vanishing twin
ICD-10	O31.2
ICD-9	651.33
DiseasesDB	31893
eMedicine	med/3411

WikiDoc Resources for Vanishing twin
Articles
Most recent articles on Vanishing twin Most cited articles on Vanishing twin Review articles on Vanishing twin Articles on Vanishing twin in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Vanishing twin Images of Vanishing twin Photos of Vanishing twin Podcasts & MP3s on Vanishing twin Videos on Vanishing twin
Evidence Based Medicine
Cochrane Collaboration on Vanishing twin Bandolier on Vanishing twin TRIP on Vanishing twin
Clinical Trials
Ongoing Trials on Vanishing twin at Clinical Trials.gov Trial results on Vanishing twin Clinical Trials on Vanishing twin at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Vanishing twin NICE Guidance on Vanishing twin NHS PRODIGY Guidance FDA on Vanishing twin CDC on Vanishing twin
Books
Books on Vanishing twin
News
Vanishing twin in the news Be alerted to news on Vanishing twin News trends on Vanishing twin
Commentary
Blogs on Vanishing twin
Definitions
Definitions of Vanishing twin
Patient Resources / Community
Patient resources on Vanishing twin Discussion groups on Vanishing twin Patient Handouts on Vanishing twin Directions to Hospitals Treating Vanishing twin Risk calculators and risk factors for Vanishing twin
Healthcare Provider Resources
Symptoms of Vanishing twin Causes & Risk Factors for Vanishing twin Diagnostic studies for Vanishing twin Treatment of Vanishing twin
Continuing Medical Education (CME)
CME Programs on Vanishing twin
International
Vanishing twin en Espanol Vanishing twin en Francais
Business
Vanishing twin in the Marketplace Patents on Vanishing twin
Experimental / Informatics
List of terms related to Vanishing twin

A vanishing twin is a fetus in a multi-gestation pregnancy which dies in utero and is then partially or completely reabsorbed by the mother Template:Harv.

The occurrence of this phenomenon is sometimes referred to as twin embolisation syndrome or vanishing twin syndrome (VTS), since the 1980s when twin pregnancies were made visible early on by means of ultrasound. The term wombtwin has been used since 2003 to describe the deceased embryo or fetus.

Occasionally, rather than being completely resorbed, the dead fetus will undergo mechanical compression by its wombmate(s), resulting in a flattened, parchment-like state known as fetus papyraceus Template:Harv.

If the fetus is absorbed completely, there are usually no further complications to the pregnancy, other than first trimester vaginal bleeding Template:Harv. However, if the event occurs in the second or third trimester, serious complications may include premature labor, infection due to the demise of the fetus, and hemorrhage. Even at the end of the pregnancy, a low-lying fetus papyraceus may block the cervix and require a cesarean to deliver the living twin.

The wombtwin can die owing to a poorly implanted placenta, a developmental anomaly that may cause major organs to fail or be missing completely, or there may be a chromosome abnormality incompatible with life. Frequently the twin is a blighted ovum, one that never developed beyond the very earliest stages of embryogenesis.

Frequency

According to Charles Template:Harvcoltxt, who is a professor in the Department of Pediatrics in the Brody School of Medicine and adjunct professor of biology at East Carolina University, vanishing twins occur in up to one out of every eight pregnancies and may not even be known in most cases.

However, Patricia J. Sulak, M.D. has reported otherwise. "In reporting 300 early pregnancies evaluated by means of ultrasound noted 21 twins, one triplet, and one quadruplet. Only three pairs of twins survived to term (85.6% loss of the second twin), whereas the triplet pregnancy evolved into a normal twin gestation, and the quadruplet pregnancy reported here also evolved into a singleton gestation. Additonally, the triplet pregnancy reported here also evolved into a pregnancy diagnosed by means of ultrasound that evolved into a twin gestation. These very high resorption rates, which cannot be explained on the basis of the expected abortion rate, again suggest intense fetal competition for space, nutrition, or other factors during early gestation, with frequent loss or resorption of the other twin(s)." Multiple gestation occurs at 7.6% in this particular study, and vanishing syndrome effect occurs within 85.6%. Therefore 6.88% of the 300 pregnancies experienced vanishing twin syndrome. Thus it seems more likely that VTS occurs 19.68 pregnancies out of 300, or about six out of every hundred pregnancies. † Article 7: The Vanishing Twin: pathologic Confirmation of an Ultrasonographic Phenomenon Sulak, M.D., L., Dodson, M.D., M.

Since it is hypothesized that in some instances vanishing twins leave no detectable trace at birth or before, it is impossible to say for certain how frequent the phenomenon is. It was hypothesized for a long time that non-righthanded and left-handed individuals may be the survivors of "mirror image" identical twinning Template:Harv but recent research does not seem to support that view Template:Harv.

"Vanishing" twins are frequently encountered in pregnancies created as a result of IVF. Ultrasound scans are taken very early in these pregnancies (5-8 weeks), so that, where a multiple conception has occurred, it frequently happens that more than one amniotic sac can be seen in early pregnancy, whereas a few weeks later there is only one to be seen and the other has "vanished" Template:Harv.

Miscellaneous

It has been speculated that the children born of such a pregnancy may have some memories of their vanished twins, and may feel lonely because of this Template:Harv. There is no scientific evidence to support this claim. Talk shows, such as Coast to Coast AM, have discussed the alleged phenomenon.

The vanishing twin syndrome has been cited by biotech company Acu-Gen as an ad hoc hypothesis to explain false results of the company's Baby Gender Mentor test. According to the company, on occasions where their pregnancy gender test has apparently given the incorrect gender of the fetus, the apparent mistake can be explained by a fetus having been present at the time of testing, but later being reabsorbed as a vanished twin. According to the company's critics, this excuse does not seem plausible.

See also

• Chimera (genetics)
• Parasitic twin
• Cerebral palsy

References

• Boklage, C.E. (1995), "Chapter 4:The frequency and survivability of natural twin conceptions", in Keith, Louis G.; Papiernik, Emile; Keith, Donald M.; Luke, Barbara, Multiple Pregnancy: Epidemiology, Gestation and Perinatal Outcome (1st ed.), New York: Taylor & Francis Group, pp. pp. 41-2, 49, ISBN 978-1850706663CS1 maint: Extra text (link)

• Hayton, Althea, ed. (2006), Untwinned; perspectives on the death of a twin before birth, St Albans, England: Wren Publications, ISBN 978-0952565499

• Jauniaux, E.; Elkazen, N.; Leroy, F.; Wilkin, P. (1988), "Clinical and morphologic aspects of the vanishing twin phenomenon", Obstetrics & Gynecology, 72 (4), pp. 577–581, PMID 3047607

• Landy, H.J.; Weiner, S.; Corson, S.L.; Batzer, F.R. (1986), "The "vanishing twin": ultrasonographic assessment of fetal disappearance in the first trimester", Am J Obstet Gynecol, 155 (1), pp. 14–19, PMID 3524235

• Medland, Sarah E.; Wright, M.J.; Geffen, G.M.; Hay, D.A. (2003), "Special Twin Environments, Genetic Influences and their Effects on the Handedness of Twins and their Siblings", Twin Research, 6 (2), pp. 119–130, PMID 12723998

• Newman, H.H. (1928), "Studies Of Human Twins II. Asymmetry Reversal, of Mirror Imaging in Identical Twins" (PDF), Biological Bulletin, 55, pp. 298–315, retrieved 2007-06-03

• Pelega, D.; Ferber, A.; Orvieto, R.; Bar-Hava, I. (1988), "Single intrauterine fetal death (fetus papyraceus) due to uterine trauma in a twin pregnancy", European Journal of Obstetrics & Gynecology and Reproductive Biology, 80 (2), pp. 175–176, PMID 9846663

• Saidi, M.H. (1988), "First-trimester bleeding and the vanishing twin. A report of three cases", J Reprod Med, 33 (10), pp. 831–4, PMID 3057206

Further reading

• Landy, H.J.; Keith, L.G. (1998), "The vanishing twin: a review" (PDF), Human Reproduction Update, 4 (2), pp. 177–183, PMID 9683354, retrieved 2007-06-03

• Pharoah, Peter O.; Price, T.S.; Plomin, R. (2002), "Cerebral palsy in twins: a national study" (PDF), Archives of Disease in Childhood Fetal and Neonatal Edition, 87 (2), pp. F122–4, PMID 12193519, retrieved 2007-06-03 (Online version required free registration)

• Pharoah, Peter O. (2005), "Causal Hypothesis for Some Congenital Anomalies", Twin Research and Human Genetics, 8 (6), pp. 543–550, PMID 16354495

External links

• Vanishing twin at eMedicine.com
• Wombtwin survivors research and support
• Vanishing twin occurrence in India
• Articles about vanishing twin phenomenon
• Photographic evidence of a vanished twin found on the placenta after delivery of the surviving twin
• LNC Newsletter - Vanishing Twin Syndrome and Fetus Papyraceus
• A review in Human Reproduction Update
• 50 articles about vanishing twin phenomenon in PubMed
• Article by Kramer with useful references