VISA (gene)

Virus-induced signaling adapter
Identifiers
Symbols	VISA ; CARDIF; DKFZp666M015; FLJ27482; FLJ41962; IPS-1; KIAA1271; MAVS
External IDs	Template:OMIM5 Template:MGI HomoloGene: 17004
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE VISA gnf1h08693 at tn.png
File:PBB GE VISA gnf1h08694 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Virus-induced signaling adapter, also known as VISA, is a human gene.

Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and RIGI (ROBO3; MIM 608630). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK; MIM 600664) and IKKB (IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1; MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005).[supplied by OMIM]

Further reading

• Nagase T, Ishikawa K, Kikuno R; et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. PMID 10574462.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Matsuda A, Suzuki Y, Honda G; et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Seth RB, Sun L, Ea CK, Chen ZJ (2005). "Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3". Cell. 122 (5): 669–82. doi:10.1016/j.cell.2005.08.012. PMID 16125763.CS1 maint: Multiple names: authors list (link)
• Kawai T, Takahashi K, Sato S; et al. (2005). "IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction". Nat. Immunol. 6 (10): 981–8. doi:10.1038/ni1243. PMID 16127453.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu LG, Wang YY, Han KJ; et al. (2005). "VISA is an adapter protein required for virus-triggered IFN-beta signaling". Mol. Cell. 19 (6): 727–40. doi:10.1016/j.molcel.2005.08.014. PMID 16153868.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Meylan E, Curran J, Hofmann K; et al. (2005). "Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus". Nature. 437 (7062): 1167–72. doi:10.1038/nature04193. PMID 16177806.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li XD, Sun L, Seth RB; et al. (2006). "Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity". Proc. Natl. Acad. Sci. U.S.A. 102 (49): 17717–22. doi:10.1073/pnas.0508531102. PMID 16301520.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Oh JH, Yang JO, Hahn Y; et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Loo YM, Owen DM, Li K; et al. (2006). "Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection". Proc. Natl. Acad. Sci. U.S.A. 103 (15): 6001–6. doi:10.1073/pnas.0601523103. PMID 16585524.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cheng G, Zhong J, Chisari FV (2006). "Inhibition of dsRNA-induced signaling in hepatitis C virus-infected cells by NS3 protease-dependent and -independent mechanisms". Proc. Natl. Acad. Sci. U.S.A. 103 (22): 8499–504. doi:10.1073/pnas.0602957103. PMID 16707574.CS1 maint: Multiple names: authors list (link)
• Lin R, Lacoste J, Nakhaei P; et al. (2006). "Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage". J. Virol. 80 (12): 6072–83. doi:10.1128/JVI.02495-05. PMID 16731946.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saha SK, Pietras EM, He JQ; et al. (2006). "Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif". EMBO J. 25 (14): 3257–63. doi:10.1038/sj.emboj.7601220. PMID 16858409.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Villén J, Gerber SA; et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Opitz B, Vinzing M, van Laak V; et al. (2007). "Legionella pneumophila induces IFNbeta in lung epithelial cells via IPS-1 and IRF3, which also control bacterial replication". J. Biol. Chem. 281 (47): 36173–9. doi:10.1074/jbc.M604638200. PMID 16984921.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen Z, Benureau Y, Rijnbrand R; et al. (2007). "GB virus B disrupts RIG-I signaling by NS3/4A-mediated cleavage of the adaptor protein MAVS". J. Virol. 81 (2): 964–76. doi:10.1128/JVI.02076-06. PMID 17093192.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hirata Y, Broquet AH, Menchén L, Kagnoff MF (2007). "Activation of innate immune defense mechanisms by signaling through RIG-I/IPS-1 in intestinal epithelial cells". J. Immunol. 179 (8): 5425–32. PMID 17911629.CS1 maint: Multiple names: authors list (link)