Undifferentiated connective tissue disease physical examination

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:

Overview

Patients with UCTD usually appear well but can present with low-grade fever, Raynaud's phenomenon, rash and Erythema nodosum. On HEENT examination, Conjunctivitis, Uveitis, Keratoconjunctivitis sicca , dry-mouth can be seen. In the neck, lymphadenopathy can be seen. Rhonchi, Wheezing , pleural friction rub and Pericardial friction rub can be heard on auscultation. On examining abdomen, tenderness in the right/left upper/lower abdominal quadrant and hepatomegaly may be noted. In the back, tenderness over the lumbar vertebrae can occur and sacral edema may be seen. Rash can be seen in the genitourinary exam. The patient can have altered mental status with psychosis and peripheral neuropathy and pitting/non-pitting edema of the lower extremities.

The presence of following findings on physical examination is highly suggestive of undifferentiated connective tissue disease(UCTD):^[1]^[2]^[3]

↑ Bodolay E, Csiki Z, Szekanecz Z, Ben T, Kiss E, Zeher M, Szücs G, Dankó K, Szegedi G (2003). "Five-year follow-up of 665 Hungarian patients with undifferentiated connective tissue disease (UCTD)". Clin. Exp. Rheumatol. 21 (3): 313–20. PMID 12846049.
↑ Mosca M, Tani C, Neri C, Baldini C, Bombardieri S (November 2006). "Undifferentiated connective tissue diseases (UCTD)". Autoimmun Rev. 6 (1): 1–4. doi:10.1016/j.autrev.2006.03.004. PMID 17110308.
↑ Mosca M, Neri R, Bombardieri S (1999). "Undifferentiated connective tissue diseases (UCTD): a review of the literature and a proposal for preliminary classification criteria". Clin. Exp. Rheumatol. 17 (5): 615–20. PMID 10544849.