Its biological activity is related primarily to the immune system function.
Tuftsin binds to specific receptors on the surface of macrophages and polymorphonuclear leukocytes, stimulating their migration, phagocytic, bactericidal, and tumoricidal activity. It also influences antibody formation.
Tuftsin has been chemically synthesized and it is considered for use in immunotherapy.
- Online Mendelian Inheritance in Man (OMIM) 191150 - "Tuftsin deficiency"
- Najjar V, Nishioka K (1970). ""Tuftsin": a natural phagocytosis stimulating peptide". Nature. 228 (5272): 672–3. PMID 4097539.