Paraprotein

Jump to navigation Jump to search

WikiDoc Resources for Paraprotein

Articles

Most recent articles on Paraprotein

Most cited articles on Paraprotein

Review articles on Paraprotein

Articles on Paraprotein in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Paraprotein

Images of Paraprotein

Photos of Paraprotein

Podcasts & MP3s on Paraprotein

Videos on Paraprotein

Evidence Based Medicine

Cochrane Collaboration on Paraprotein

Bandolier on Paraprotein

TRIP on Paraprotein

Clinical Trials

Ongoing Trials on Paraprotein at Clinical Trials.gov

Trial results on Paraprotein

Clinical Trials on Paraprotein at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Paraprotein

NICE Guidance on Paraprotein

NHS PRODIGY Guidance

FDA on Paraprotein

CDC on Paraprotein

Books

Books on Paraprotein

News

Paraprotein in the news

Be alerted to news on Paraprotein

News trends on Paraprotein

Commentary

Blogs on Paraprotein

Definitions

Definitions of Paraprotein

Patient Resources / Community

Patient resources on Paraprotein

Discussion groups on Paraprotein

Patient Handouts on Paraprotein

Directions to Hospitals Treating Paraprotein

Risk calculators and risk factors for Paraprotein

Healthcare Provider Resources

Symptoms of Paraprotein

Causes & Risk Factors for Paraprotein

Diagnostic studies for Paraprotein

Treatment of Paraprotein

Continuing Medical Education (CME)

CME Programs on Paraprotein

International

Paraprotein en Espanol

Paraprotein en Francais

Business

Paraprotein in the Marketplace

Patents on Paraprotein

Experimental / Informatics

List of terms related to Paraprotein

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


A paraprotein is an abnormal protein in the urine or blood, most often associated with benign MGUS (monoclonal gammopathy of undetermined significance), where they remain "silent",[1] and multiple myeloma. An excess in the blood is known as paraproteinemia.

These are immunoglobulins or immunoglobulin light-chains that are produced by the clonal proliferation of plasma cells. Paraproteins form a narrow band, or 'spike' in protein electrophoresis as they are all exactly the same protein.

Monoclonal free light chains in the serum or urine are called Bence Jones proteins.

History

The concept and term were introduced by the Berlin pathologist Dr Kurt Apitz in 1940,[2] at that time the Oberarzt of the pathological institute at the Charité hospital.[3]

Paraproteins allowed the detailed study of immunoglobulins, which eventually led to the production of monoclonal antibodies in 1975.

References

  1. Maniatis A (1998). "Pathophysiology of paraprotein production". Ren Fail. 20 (6): 821–8. PMID 9834980.
  2. Apitz K. Die Paraproteinosen. Über die Störungen des Eiweißstoffwechsels bei Plasmozytomen. Virchows Arch Pathol Anat 1940;306:630-699.
  3. McDevitt HO. Albert Hewett Coons. In: "Biographical Memoirs", National Academy of Sciences 1996;69:26-37. ISBN 0-309-05346-3. Fulltext.

External links

See also

he:פאראפרוטאין


Template:WikiDoc Sources