Tuberculosis/History And Symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]; Associate Editor(s)-in-Chief: Mashal Awais, M.D.[3]; Alejandro Lemor, M.D. [4]
Overview
weakness, weight loss, fever, and night sweats are common general symptoms of tuberculosis. Symptoms of pulmonary tuberculosis include pulmonary tuberculosis cough, hemoptysis, and chest pain. It is difficult to diagnose tuberculosis in children, as these may lack the classic common findings.
History and Symptoms
Physicians should be mindful of the patient’s history of TB exposure, infection, or disease. In addition, it is also important to consider demographic factors (e.g., country of origin, age, ethnic or racial group, occupation) that may increase the individual’s risk for TB exposure or to drug-resistant TB. Also, physicians should figure out other medical conditions that can decrease the immunity, especially HIV infection, which increase the risk of latent TB infection progression to active TB disease.
Pulmonary Tuberculosis
In case of active tuberculosis, 75% of the cases present with lung involvement. Suspect Pulmonary tuberculosis in any individual who has the following symptoms:[1]
- Cough (most common symptom)
- Fever
- Night sweats
- Unexplained weight loss
- Hemoptysis
- Chest pain
- Anorexia
- Malaise
- Chills
- Fatigue
- Dyspnea
- Lymphadenopathy
Extra-Pulmonary Tuberculosis
- The rest of the active tuberculosis cases (other 25%) of active cases spread from the lungs, causing other forms of TB that are more common in immunosuppressed individuals and young children.
- disseminated TB is a serious form of TB that is also known as miliary tuberculosis. Extrapulmonary TB is not contagious; however, it may co-exist with pulmonary TB, that is contagious.[2]
All forms of extra-pulmonary tuberculosis may present with the symptoms of pulmonary tuberculosis such as malaise, night sweats, cough, weight loss, and also may be associated with an active pulmonary infection.
| Extra-Pulmonary Location | History and Symptoms |
|---|---|
| Tuberculous Lymphadenitis | Fever, painless lymph node swelling. |
| Pott's disease/Skeletal Tuberculosis | Low back pain, stiffness, pain in the affected joint or extremity, joint swelling, limited mobility. |
| Central Nervous System Tuberculosis | Headache, seizures, weakness, vomiting. |
| Tuberculous Peritonitis | Abdominal pain, fever, ascites |
| Tuberculous Pericarditis | chest pain,Shortness of breath, cough, pedal edema. |
| Renal Tuberculosis | Symptoms of UTI, include polyuria, dysuria, hematuria, flank pain Symptoms of obstructive uropathy, such as oliguria or anuria, pelvic pain. |
| Adapted from Asian Spine J. Feb 2014; 8(1): 97–111[3]; Handbook of Clinical Neurology[4]Circulation Dec 2005 vol.112 no.23 3608-3616[5]; Am J Trop Med Hyg 2013 vol. 88 no. 1 54-64[6]; Clin Infect Dis.(2011)53(6):555-562.[7] | |
References
- ↑ Mandell, Gerald (2010). Mandell, Douglas, and Bennett's principles and practice of infectious diseases. Philadelphia, PA: Churchill Livingstone/Elsevier. ISBN 0443068399.
- ↑ Centers for Disease Control and Prevention (CDC), Division of Tuberculosis Elimination. Core Curriculum on Tuberculosis: What the Clinician Should Know. 4th edition (2000). Updated Aug 2003.
- ↑ Moon, Myung-Sang (2014). "Tuberculosis of Spine: Current Views in Diagnosis and Management". Asian Spine Journal. 8 (1): 97. doi:10.4184/asj.2014.8.1.97. ISSN 1976-1902.
- ↑ Garcia-Monco, Juan Carlos (2014). "Tuberculosis". 121: 1485–1499. doi:10.1016/B978-0-7020-4088-7.00100-0. ISSN 0072-9752.
- ↑ Mayosi, B. M. (2005). "Tuberculous Pericarditis". Circulation. 112 (23): 3608–3616. doi:10.1161/CIRCULATIONAHA.105.543066. ISSN 0009-7322.
- ↑ Daher, E. D. F.; da Silva Junior, G. B.; Barros, E. J. G. (2013). "Renal Tuberculosis in the Modern Era". American Journal of Tropical Medicine and Hygiene. 88 (1): 54–64. doi:10.4269/ajtmh.2013.12-0413. ISSN 0002-9637.
- ↑ Fontanilla, J.-M.; Barnes, A.; von Reyn, C. F. (2011). "Current Diagnosis and Management of Peripheral Tuberculous Lymphadenitis". Clinical Infectious Diseases. 53 (6): 555–562. doi:10.1093/cid/cir454. ISSN 1058-4838.
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