Trigeminal neuralgia other imaging findings

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MRI/MRA are the main imaging modalities used to distinguish between classic, secondary and idiopathic forms of trigeminal neuralgia. Some other tests performed include:


Although not a diagnostic test histology reveals focal demyelination as the ultimate lesion in all cases of trigeminal neuralgia.[1]

Clinical Neurophysiology testing

Clinical neurophysiology testing with a blink reflex study may be helpful to demonstrate a lesion of the trigeminus in which a bilateral delay occurs in response to the stimulation on the pathologic side. The blink reflex can clearly help to distinguish idiopathic form of trigeminal neuralgia from other causes. The sensitivity of this test across studies has been reported as 59-100%, and the specificity has been noted as 93-100%.[1][2]


  1. 1.0 1.1 "Trigeminal Neuralgia Workup: Approach Considerations, Magnetic Resonance Imaging, Magnetic Resonance Angiography".
  2. Cruccu G, Biasiotta A, Galeotti F, Iannetti GD, Truini A, Gronseth G. Diagnostic accuracy of trigeminal reflex testing in trigeminal neuralgia. Neurology. 2006 Jan 10. 66(1):139-41

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