Trigeminal neuralgia epidemiology and demographics

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TN is a rare condition that affects women more than men. The annual incidence of TN is 4 to 13 per 100,000 people.[1][2]Despite its low incidence, numbers may be significantly higher due to frequent misdiagnosis. TN is one of the more frequently seen neuralgias in the older adult population. The incidence increases gradually with age; most idiopathic cases begin after age 50, although onset may occur in the second and third decades or, rarely, in children.[3]

The male-to-female prevalence ratio of TN ranges from 1:1.5 to 1:1.7.[4] This female predominance may be related to the increased longevity of women compared with men. Rare familial cases have been reported, but the vast majority of patients have sporadic disease.[5]


  1. Katusic S, Williams DB, Beard CM, Bergstralh EJ, Kurland LT (1991). "Epidemiology and clinical features of idiopathic trigeminal neuralgia and glossopharyngeal neuralgia: similarities and differences, Rochester, Minnesota, 1945-1984". Neuroepidemiology. 10 (5–6): 276–81. doi:10.1159/000110284. PMID 1798430.
  2. MacDonald BK, Cockerell OC, Sander JW, Shorvon SD (April 2000). "The incidence and lifetime prevalence of neurological disorders in a prospective community-based study in the UK". Brain. 123 ( Pt 4): 665–76. PMID 10733998.
  3. Childs AM, Meaney JF, Ferrie CD, Holland PC (April 2000). "Neurovascular compression of the trigeminal and glossopharyngeal nerve: three case reports". Arch. Dis. Child. 82 (4): 311–5. PMC 1718296. PMID 10735840.
  4. Katusic S, Beard CM, Bergstralh E, Kurland LT (January 1990). "Incidence and clinical features of trigeminal neuralgia, Rochester, Minnesota, 1945-1984". Ann. Neurol. 27 (1): 89–95. doi:10.1002/ana.410270114. PMID 2301931.
  5. Fleetwood IG, Innes AM, Hansen SR, Steinberg GK (September 2001). "Familial trigeminal neuralgia. Case report and review of the literature". J. Neurosurg. 95 (3): 513–7. doi:10.3171/jns.2001.95.3.0513. PMID 11565877.

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