TTLL3

Jump to navigation Jump to search
VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Tubulin tyrosine ligase-like family, member 3 is a protein that in humans is encoded by the TTLL3 gene.[1]

Model organisms

Model organisms have been used in the study of TTLL3 function. A conditional knockout mouse line, called Ttll3tm1a(EUCOMM)Wtsi[6][7] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[8][9][10]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[4][11] Twenty three tests were carried out on mutant mice but no significant abnormalities were observed.[4]

References

  1. ↑ "Entrez Gene: Tubulin tyrosine ligase-like family, member 3". Retrieved 2011-09-21.
  2. ↑ "Salmonella infection data for Ttll3". Wellcome Trust Sanger Institute.
  3. ↑ "Citrobacter infection data for Ttll3". Wellcome Trust Sanger Institute.
  4. ↑ 4.0 4.1 4.2 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x.
  5. ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  6. ↑ "International Knockout Mouse Consortium".
  7. ↑ "Mouse Genome Informatics".
  8. ↑ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  9. ↑ Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  10. ↑ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  11. ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading

  • Trichet, V.; Ruault, M.; Roizès, G.; De Sario, A. (2000). "Characterization of the human tubulin tyrosine ligase-like 1 gene (TTLL1) mapping to 22q13.1". Gene. 257 (1): 109–117. doi:10.1016/S0378-1119(00)00383-8. PMID 11054573.
  • Rogowski, K.; Juge, F. O.; Van Dijk, J.; Wloga, D.; Strub, J. M.; Levilliers, N.; Thomas, D.; Bré, M. H. L. N.; Van Dorsselaer, A.; Gaertig, J.; Janke, C. (2009). "Evolutionary Divergence of Enzymatic Mechanisms for Posttranslational Polyglycylation". Cell. 137 (6): 1076–1087. doi:10.1016/j.cell.2009.05.020. PMID 19524510.


Retrieved from "https://www.wikidoc.org/index.php?title=TTLL3&oldid=1532433"