TGFBR2

Transforming growth factor, beta receptor II (70/80kDa)
File:PBB Protein TGFBR2 image.jpg PDB rendering based on 1ktz.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1ktz​, 1m9z​, 1plo​
Identifiers
Symbols	TGFBR2 ; AAT3; FAA3; HNPCC6; MFS2; RIIC; TAAD2; TGFR-2; TGFbeta-RII
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2435
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE TGFBR2 208944 at tn.png
File:PBB GE TGFBR2 207334 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Transforming growth factor, beta receptor II (70/80kDa), also known as TGFBR2, is a human gene.

This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.

See also

• TGF beta receptors