TGFBR1

Transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)
File:PBB Protein TGFBR1 image.jpg PDB rendering based on 1b6c.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1b6c​, 1ias​, 1py5​, 1rw8​, 1vjy​
Identifiers
Symbols	TGFBR1 ; ACVRLK4; AAT5; ALK-5; ALK5; SKR4; TGFR-1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3177
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa), also known as TGFBR1, is a human gene.

The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).

See also

• TGF beta receptors

Further reading

• Massagué J (1992). "Receptors for the TGF-beta family". Cell. 69 (7): 1067–70. PMID 1319842.
• Wrana JL (1998). "TGF-beta receptors and signalling mechanisms". Mineral and electrolyte metabolism. 24 (2–3): 120–30. PMID 9525694.
• Josso N, di Clemente N, Gouédard L (2001). "Anti-Müllerian hormone and its receptors". Mol. Cell. Endocrinol. 179 (1–2): 25–32. PMID 11420127.CS1 maint: Multiple names: authors list (link)