Sodium-glucose co-transporter 2

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List of terms related to Sodium-glucose co-transporter 2

solute carrier family 5 (sodium/glucose cotransporter), member 2
Identifiers
Symbol	SLC5A2
Alt. symbols	SGLT2
Entrez	6524
HUGO	11037
OMIM	182381
RefSeq	NM_003041
UniProt	P31639
Other data
Locus	Chr. 16 p11.2

Overview

Sodium-dependent glucose cotrasporter 2 are a family of glucose transporter "expressed in the luminal membrane of the proximal kidney tubules"^[1]. They contribute to renal glucose reabsorption.

Pharmacology

Inhibitors

Canagliflozin
Dapagliflozin
Empagliflozin
Gliflozin

Inhibitors improve glycemic control^[2] and may reduce clinical outcomes^[3].

References

↑ Anonymous 2015, co-transporter 2 Sodium-glucose co-transporter 2. Medical Subject Headings. U.S. National Library of Medicine.
↑ Vasilakou D, Karagiannis T, Athanasiadou E, Mainou M, Liakos A, Bekiari E; et al. (2013). "Sodium-glucose cotransporter 2 inhibitors for type 2 diabetes: a systematic review and meta-analysis". Ann Intern Med. 159 (4): 262–74. doi:10.7326/0003-4819-159-4-201308200-00007. PMID 24026259. Review in: Ann Intern Med. 2014 Jan 21;160(2):JC10
↑ Zinman B, Wanner C, Lachin JM, Fitchett D, Bluhmki E, Hantel S; et al. (2015). "Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes". N Engl J Med. doi:10.1056/NEJMoa1504720. PMID 26378978.

External links

Sodium-Glucose+Transporter+2 at the US National Library of Medicine Medical Subject Headings (MeSH)

[1] Anonymous 2015, co-transporter 2 Sodium-glucose co-transporter 2. Medical Subject Headings. U.S. National Library of Medicine.

[pmid24026259-2] Vasilakou D, Karagiannis T, Athanasiadou E, Mainou M, Liakos A, Bekiari E; et al. (2013). "Sodium-glucose cotransporter 2 inhibitors for type 2 diabetes: a systematic review and meta-analysis". Ann Intern Med. 159 (4): 262–74. doi:10.7326/0003-4819-159-4-201308200-00007. PMID 24026259. Review in: Ann Intern Med. 2014 Jan 21;160(2):JC10

[pmid26378978-3] Zinman B, Wanner C, Lachin JM, Fitchett D, Bluhmki E, Hantel S; et al. (2015). "Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes". N Engl J Med. doi:10.1056/NEJMoa1504720. PMID 26378978.

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