SLC37A1

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Solute carrier family 37 (glucose-6-phosphate transporter), member 1 is a protein that in humans is encoded by the SLC37A1 gene.[1] SLC37A1 locates to the membrane of the endoplasmic reticulum (ER), and is a glucose 6-phosphate:inorganic phosphate antiporter, transporting glucose 6-phosphate from the cytoplasm into the lumen of the ER, while transporting phosphate in the opposite direction.[2]

Unlike the related SLC37A4 protein, SLC37A1 does not appear to be involved in blood glucose homeostasis[3], but does appear to regulate phosphate levels in the milk of cows, with flow-on effects on the volume of milk produced.[4]

References

  1. ↑ "Entrez Gene: Solute carrier family 37 (glucose-6-phosphate transporter), member 1".
  2. ↑ "SLC37A1 - Glucose-6-phosphate exchanger SLC37A1 - Homo sapiens (Human) - SLC37A1 gene & protein".
  3. ↑ Pan CJ, Chen SY, Jun HS, Lin SR, Mansfield BC, Chou JY (2011). "SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters". PLoS One. 6 (9): e23157. doi:10.1371/journal.pone.0023157. PMC 3176764. PMID 21949678.
  4. ↑ Kemper KE, Littlejohn MD, Lopdell T, Hayes BJ, Bennett LE, Williams RP, Xu XQ, Visscher PM, Carrick MJ, Goddard ME (2016). "Leveraging genetically simple traits to identify small-effect variants for complex phenotypes". BMC Genomics. 17: 858. doi:10.1186/s12864-016-3175-3. PMC 5094043. PMID 27809761.

Further reading

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