Sodium–hydrogen antiporter 1

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

The sodium-hydrogen antiporter 1 (NHE-1) also known as sodium/hydrogen exchanger 1 or SLC9A1 (SoLute Carrier family 9A1) is an isoform of sodium–hydrogen antiporter that in humans is encoded by the SLC9A1 gene.

Function

The Na⁺/H⁺ antiporter (SLC9A1) is a ubiquitous membrane-bound enzyme involved in volume- and pH-regulation of vertebrate cells. It is inhibited by the non-specific diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, tumor promoters, and others.

Interactions

Sodium–hydrogen antiporter 1 has been shown to interact with carbonic anhydrase II and CHP. It is also the target of the experimental drug rimeporide, which is being developed for the treatment of Duchenne muscular dystrophy.

Further reading

• Yu L, Quinn DA, Garg HG, Hales CA (June 2008). "Deficiency of the NHE1 gene prevents hypoxia-induced pulmonary hypertension and vascular remodeling". Am. J. Respir. Crit. Care Med. 177 (11): 1276–84. doi:10.1164/rccm.200710-1522OC. PMC 2408441. PMID 18310478.
• Rios EJ, Fallon M, Wang J, Shimoda LA (November 2005). "Chronic hypoxia elevates intracellular pH and activates Na+/H+ exchange in pulmonary arterial smooth muscle cells". Am. J. Physiol. Lung Cell Mol. Physiol. 289 (5): L867–74. doi:10.1152/ajplung.00455.2004. PMID 15964895.
• Cingolani HE, Ennis IL (2007). "Sodium-hydrogen exchanger, cardiac overload, and myocardial hypertrophy". Circulation. 115 (9): 1090–100. doi:10.1161/CIRCULATIONAHA.106.626929. PMID 17339567.
• Meima ME, Mackley JR, Barber DL (2007). "Beyond ion translocation: structural functions of the sodium-hydrogen exchanger isoform-1". Curr. Opin. Nephrol. Hypertens. 16 (4): 365–72. doi:10.1097/MNH.0b013e3281bd888d. PMID 17565280.
• Tse CM, Ma AI, Yang VW, Watson AJ, Levine S, Montrose MH, Potter J, Sardet C, Pouyssegur J, Donowitz M (1991). "Molecular cloning and expression of a cDNA encoding the rabbit ileal villus cell basolateral membrane Na+/H+ exchanger". EMBO J. 10 (8): 1957–67. PMC 452875. PMID 1712287.
• Dudley CR, Giuffra LA, Tippett P, Kidd KK, Reeders ST (1990). "The Na+/H+ antiporter: a "melt" polymorphism allows regional mapping to the short arm of chromosome 1". Hum. Genet. 86 (1): 79–83. doi:10.1007/bf00205179. PMID 1979310.
• Sardet C, Counillon L, Franchi A, Pouysségur J (1990). "Growth factors induce phosphorylation of the Na+/H+ antiporter, glycoprotein of 110 kD". Science. 247 (4943): 723–6. doi:10.1126/science.2154036. PMID 2154036.
• Sardet C, Franchi A, Pouysségur J (1989). "Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter". Cell. 56 (2): 271–80. doi:10.1016/0092-8674(89)90901-X. PMID 2536298.
• Mattei MG, Sardet C, Franchi A, Pouysségur J (1988). "The human amiloride-sensitive Na+/H+ antiporter: localization to chromosome 1 by in situ hybridization". Cytogenet. Cell Genet. 48 (1): 6–8. doi:10.1159/000132575. PMID 2846238.
• Counillon L, Pouysségur J, Reithmeier RA (1994). "The Na+/H+ exchanger NHE-1 possesses N- and O-linked glycosylation restricted to the first N-terminal extracellular domain". Biochemistry. 33 (34): 10463–9. doi:10.1021/bi00200a030. PMID 8068684.
• Fliegel L, Dyck JR, Wang H, Fong C, Haworth RS (1993). "Cloning and analysis of the human myocardial Na+/H+ exchanger". Mol. Cell. Biochem. 125 (2): 137–43. doi:10.1007/BF00936442. PMID 8283968.
• Lin X, Barber DL (1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange". Proc. Natl. Acad. Sci. U.S.A. 93 (22): 12631–6. doi:10.1073/pnas.93.22.12631. PMC 38044. PMID 8901634.
• Shrode LD, Gan BS, D'Souza SJ, Orlowski J, Grinstein S (1998). "Topological analysis of NHE1, the ubiquitous Na+/H+ exchanger using chymotryptic cleavage". Am. J. Physiol. 275 (2 Pt 1): C431–9. PMID 9688597.
• Wakabayashi S, Pang T, Su X, Shigekawa M (2000). "A novel topology model of the human Na(+)/H(+) exchanger isoform 1". J. Biol. Chem. 275 (11): 7942–9. doi:10.1074/jbc.275.11.7942. PMID 10713111.
• Garden OA, Musk P, Worthington-White DA, Dewey MJ, Rich IN (2000). "Silent polymorphisms within the coding region of human sodium/hydrogen exchanger isoform-1 cDNA in peripheral blood mononuclear cells of leukemia patients: A comparison with healthy controls". Cancer Genet. Cytogenet. 120 (1): 37–43. doi:10.1016/S0165-4608(99)00246-0. PMID 10913675.
• Denker SP, Huang DC, Orlowski J, Furthmayr H, Barber DL (2000). "Direct binding of the Na--H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H(+) translocation". Mol. Cell. 6 (6): 1425–36. doi:10.1016/S1097-2765(00)00139-8. PMID 11163215.
• Lehoux S, Florian JA, Berk BC (2001). "14-3-3 Binding to Na+/H+ exchanger isoform-1 is associated with serum-dependent activation of Na+/H+ exchange". J. Biol. Chem. 276 (19): 15794–800. doi:10.1074/jbc.M100410200. PMID 11279064.
• Pang T, Su X, Wakabayashi S, Shigekawa M (2001). "Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers". J. Biol. Chem. 276 (20): 17367–72. doi:10.1074/jbc.M100296200. PMID 11350981.
• Yan W, Nehrke K, Choi J, Barber DL (2001). "The Nck-interacting kinase (NIK) phosphorylates the Na+-H+ exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor". J. Biol. Chem. 276 (33): 31349–56. doi:10.1074/jbc.M102679200. PMID 11369779.
• Khaled AR, Moor AN, Li A, Kim K, Ferris DK, Muegge K, Fisher RJ, Fliegel L, Durum SK (2001). "Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization". Mol. Cell. Biol. 21 (22): 7545–57. doi:10.1128/MCB.21.22.7545-7557.2001. PMC 99926. PMID 11604491.
• Mailänder J, Müller-Esterl W, Dedio J (2001). "Human homolog of mouse tescalcin associates with Na(+)/H(+) exchanger type-1". FEBS Lett. 507 (3): 331–5. doi:10.1016/S0014-5793(01)02986-6. PMID 11696366.
• Shen MR, Wilkins RJ, Chou CY, Ellory JC (2002). "Anion exchanger isoform 2 operates in parallel with Na(+)/H(+) exchanger isoform 1 during regulatory volume decrease of human cervical cancer cells". FEBS Lett. 512 (1–3): 52–8. doi:10.1016/S0014-5793(01)03317-8. PMID 11852051.
• Behne MJ, Meyer JW, Hanson KM, Barry NP, Murata S, Crumrine D, Clegg RW, Gratton E, Holleran WM, Elias PM, Mauro TM (2002). "NHE1 regulates the stratum corneum permeability barrier homeostasis. Microenvironment acidification assessed with fluorescence lifetime imaging". J. Biol. Chem. 277 (49): 47399–406. doi:10.1074/jbc.M204759200. PMID 12221084.