Signaling lymphocytic activation molecule

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Signaling lymphocytic activation molecule

Signaling lymphocytic activation molecule is a family of genes. Homophilic binding between SLAMs is involved in cellular adhesion [1][2]

Signaling lymphocytic activation molecule (SLAM) is a CD2-related surface receptor expressed by activated T cells and B cells. SLAM is a self ligand and enhances T cellular proliferation and IFN-gamma production.

A defective SLAM associated protein (SAP) causes X-linked lymphoproliferative syndrome (XLP), a frequently lethal mononucleosis based on the inability to control EBV

Members of the family include:


  1. "SLAM FAMILY, MEMBER 1". OMIM. Retrieved 19 March 2014.
  2. Rosenbach T, Csatò M, Czarnetzki BM (January 1988). "Studies on the role of leukotrienes in murine allergic and irritant contact dermatitis". The British Journal of Dermatology. 118 (1): 1–6. doi:10.1111/j.1365-2133.1988.tb01743.x. PMID 2829957.
  3. Sintes J, Engel P (February 2011). "SLAM (CD150) is a multitasking immunoreceptor: from cosignalling to bacterial recognition". Immunology and Cell Biology. 89 (2): 161–3. doi:10.1038/icb.2010.145. PMID 21102539.
  4. Chatterjee M, Kis-Toth K, Thai TH, Terhorst C, Tsokos GC (May 2011). "SLAMF6-driven co-stimulation of human peripheral T cells is defective in SLE T cells". Autoimmunity. 44 (3): 211–8. doi:10.3109/08916934.2010.530627. PMC 4465387. PMID 21231893.
  5. Kim JR, Horton NC, Mathew SO, Mathew PA (August 2013). "CS1 (SLAMF7) inhibits production of proinflammatory cytokines by activated monocytes". Inflammation Research. 62 (8): 765–72. doi:10.1007/s00011-013-0632-1. PMID 23695528.
  6. Wang G, Abadía-Molina AC, Berger SB, Romero X, O'Keeffe MS, Rojas-Barros DI, Aleman M, Liao G, Maganto-García E, Fresno M, Wang N, Detre C, Terhorst C (June 2012). "Cutting edge: Slamf8 is a negative regulator of Nox2 activity in macrophages". Journal of Immunology. 188 (12): 5829–32. doi:10.4049/jimmunol.1102620. PMC 3370125. PMID 22593622.
  7. Pott S, Kamrani NK, Bourque G, Pettersson S, Liu ET (2012). Jothi R, ed. "PPARG binding landscapes in macrophages suggest a genome-wide contribution of PU.1 to divergent PPARG binding in human and mouse". PLOS One. 7 (10): e48102. doi:10.1371/journal.pone.0048102. PMC 3485280. PMID 23118933.