SLC25A4

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

ADP/ATP translocase 1 is an enzyme that in humans is encoded by the SLC25A4 gene or adenine nucleotide translocator, ANT.

Interactions

SLC25A4 has been shown to interact with Bcl-2-associated X protein.

Further reading

• Vieira HL, Haouzi D, El Hamel C, Jacotot E, Belzacq AS, Brenner C, Kroemer G (Dec 2000). "Permeabilization of the mitochondrial inner membrane during apoptosis: impact of the adenine nucleotide translocator". Cell Death and Differentiation. 7 (12): 1146–54. doi:10.1038/sj.cdd.4400778. PMID 11175251.
• Ferri KF, Jacotot E, Blanco J, Esté JA, Kroemer G (2001). "Mitochondrial control of cell death induced by HIV-1-encoded proteins". Annals of the New York Academy of Sciences. 926: 149–64. doi:10.1111/j.1749-6632.2000.tb05609.x. PMID 11193032.
• Kino T, Pavlakis GN (Apr 2004). "Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1". DNA and Cell Biology. 23 (4): 193–205. doi:10.1089/104454904773819789. PMID 15142377.
• Andersen JL, Planelles V (Jan 2005). "The role of Vpr in HIV-1 pathogenesis". Current HIV Research. 3 (1): 43–51. doi:10.2174/1570162052772988. PMID 15638722.
• Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology. 2: 11. doi:10.1186/1742-4690-2-11. PMC 554975. PMID 15725353.
• Zhao RY, Bukrinsky M, Elder RT (Apr 2005). "HIV-1 viral protein R (Vpr) & host cellular responses". The Indian Journal of Medical Research. 121 (4): 270–86. PMID 15817944.
• Muthumani K, Choo AY, Premkumar A, Hwang DS, Thieu KP, Desai BM, Weiner DB (Aug 2005). "Human immunodeficiency virus type 1 (HIV-1) Vpr-regulated cell death: insights into mechanism". Cell Death and Differentiation. 12 Suppl 1: 962–70. doi:10.1038/sj.cdd.4401583. PMID 15832179.
• Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions". Cell Research. 15 (11–12): 923–34. doi:10.1038/sj.cr.7290370. PMID 16354571.
• Moon HS, Yang JS (Feb 2006). "Role of HIV Vpr as a regulator of apoptosis and an effector on bystander cells". Molecules and Cells. 21 (1): 7–20. PMID 16511342.
• Cozens AL, Runswick MJ, Walker JE (Mar 1989). "DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase". Journal of Molecular Biology. 206 (2): 261–80. doi:10.1016/0022-2836(89)90477-4. PMID 2541251.
• Li K, Warner CK, Hodge JA, Minoshima S, Kudoh J, Fukuyama R, Maekawa M, Shimizu Y, Shimizu N, Wallace DC (Aug 1989). "A human muscle adenine nucleotide translocator gene has four exons, is located on chromosome 4, and is differentially expressed". The Journal of Biological Chemistry. 264 (24): 13998–4004. PMID 2547778.
• Neckelmann N, Li K, Wade RP, Shuster R, Wallace DC (Nov 1987). "cDNA sequence of a human skeletal muscle ADP/ATP translocator: lack of a leader peptide, divergence from a fibroblast translocator cDNA, and coevolution with mitochondrial DNA genes". Proceedings of the National Academy of Sciences of the United States of America. 84 (21): 7580–4. doi:10.1073/pnas.84.21.7580. PMC 299343. PMID 2823266.
• Houldsworth J, Attardi G (Jan 1988). "Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver". Proceedings of the National Academy of Sciences of the United States of America. 85 (2): 377–81. doi:10.1073/pnas.85.2.377. PMC 279551. PMID 2829183.
• Wijmenga C, Winokur ST, Padberg GW, Skraastad MI, Altherr MR, Wasmuth JJ, Murray JC, Hofker MH, Frants RR (Sep 1993). "The human skeletal muscle adenine nucleotide translocator gene maps to chromosome 4q35 in the region of the facioscapulohumeral muscular dystrophy locus". Human Genetics. 92 (2): 198–203. doi:10.1007/BF00219692. PMID 8103757.
• Bakker HD, Scholte HR, Van den Bogert C, Ruitenbeek W, Jeneson JA, Wanders RJ, Abeling NG, Dorland B, Sengers RC, Van Gennip AH (Apr 1993). "Deficiency of the adenine nucleotide translocator in muscle of a patient with myopathy and lactic acidosis: a new mitochondrial defect". Pediatric Research. 33 (4 Pt 1): 412–7. doi:10.1203/00006450-199304000-00019. PMID 8479824.
• Kaukonen JA, Amati P, Suomalainen A, Rötig A, Piscaglia MG, Salvi F, Weissenbach J, Fratta G, Comi G, Peltonen L, Zeviani M (Apr 1996). "An autosomal locus predisposing to multiple deletions of mtDNA on chromosome 3p". American Journal of Human Genetics. 58 (4): 763–9. PMC 1914672. PMID 8644740.
• Marzo I, Brenner C, Zamzami N, Jürgensmeier JM, Susin SA, Vieira HL, Prévost MC, Xie Z, Matsuyama S, Reed JC, Kroemer G (Sep 1998). "Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis". Science. 281 (5385): 2027–31. doi:10.1126/science.281.5385.2027. PMID 9748162.
• Kaukonen J, Zeviani M, Comi GP, Piscaglia MG, Peltonen L, Suomalainen A (Jul 1999). "A third locus predisposing to multiple deletions of mtDNA in autosomal dominant progressive external ophthalmoplegia". American Journal of Human Genetics. 65 (1): 256–61. doi:10.1086/302445. PMC 1378100. PMID 10364542.
• Jacotot E, Ravagnan L, Loeffler M, Ferri KF, Vieira HL, Zamzami N, Costantini P, Druillennec S, Hoebeke J, Briand JP, Irinopoulou T, Daugas E, Susin SA, Cointe D, Xie ZH, Reed JC, Roques BP, Kroemer G (Jan 2000). "The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore". The Journal of Experimental Medicine. 191 (1): 33–46. doi:10.1084/jem.191.1.33. PMC 2195797. PMID 10620603.

External links

• SLC25A4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)