The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.[3]
↑Davila S, Furu L, Gharavi AG, Tian X, Onoe T, Qian Q, Li A, Cai Y, Kamath PS, King BF, Azurmendi PJ, Tahvanainen P, Kääriäinen H, Höckerstedt K, Devuyst O, Pirson Y, Martin RS, Lifton RP, Tahvanainen E, Torres VE, Somlo S (June 2004). "Mutations in SEC63 cause autosomal dominant polycystic liver disease". Nat. Genet. 36 (6): 575–7. doi:10.1038/ng1357. PMID15133510.
Further reading
Meyer HA, Grau H, Kraft R, et al. (2000). "Mammalian Sec61 is associated with Sec62 and Sec63". J. Biol. Chem. 275 (19): 14550–7. doi:10.1074/jbc.275.19.14550. PMID10799540.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Davila S, Furu L, Gharavi AG, et al. (2004). "Mutations in SEC63 cause autosomal dominant polycystic liver disease". Nat. Genet. 36 (6): 575–7. doi:10.1038/ng1357. PMID15133510.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID16303743.
