RCC1

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Species	Human	Mouse
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Regulator of chromosome condensation 1, also known as RCC1, Ran guanine nucleotide exchange factor and RanGEF, is the name for a human gene and protein.

RCC1 also functions as a guanine nucleotide exchange factor for Ran GTPase.

Interactions

RCC1 has been shown to interact with RANBP3 and Ran (biology).

Further reading

• Furuno N, Nakagawa K, Eguchi U, et al. (1992). "Complete nucleotide sequence of the human RCC1 gene involved in coupling between DNA replication and mitosis". Genomics. 11 (2): 459–61. doi:10.1016/0888-7543(91)90156-9. PMID 1769659.
• Bischoff FR, Ponstingl H (1991). "Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1". Nature. 354 (6348): 80–2. Bibcode:1991Natur.354...80B. doi:10.1038/354080a0. PMID 1944575.
• Bischoff FR, Ponstingl H (1992). "Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide". Proc. Natl. Acad. Sci. U.S.A. 88 (23): 10830–4. Bibcode:1991PNAS...8810830B. doi:10.1073/pnas.88.23.10830. PMC 53025. PMID 1961752.
• Bischoff FR, Maier G, Tilz G, Ponstingl H (1990). "A 47-kDa human nuclear protein recognized by antikinetochore autoimmune sera is homologous with the protein encoded by RCC1, a gene implicated in onset of chromosome condensation". Proc. Natl. Acad. Sci. U.S.A. 87 (21): 8617–21. Bibcode:1990PNAS...87.8617B. doi:10.1073/pnas.87.21.8617. PMC 55008. PMID 2236072.
• Ohtsubo M, Okazaki H, Nishimoto T (1989). "The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA". J. Cell Biol. 109 (4 Pt 1): 1389–97. doi:10.1083/jcb.109.4.1389. PMC 2115805. PMID 2677018.
• Ohtsubo M, Kai R, Furuno N, et al. (1987). "Isolation and characterization of the active cDNA of the human cell cycle gene (RCC1) involved in the regulation of onset of chromosome condensation". Genes Dev. 1 (6): 585–93. doi:10.1101/gad.1.6.585. PMID 3678831.
• Hayashi N, Yokoyama N, Seki T, et al. (1995). "RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4". Mol. Gen. Genet. 247 (6): 661–9. doi:10.1007/BF00290397. PMID 7616957.
• Nishimoto T, Seino H, Seki N, Hori TA (1995). "The human CHC1 gene encoding RCC1 (regulator of chromosome condensation) (CHC1) is localized to human chromosome 1p36.1". Genomics. 23 (3): 719–21. doi:10.1006/geno.1994.1570. PMID 7851910.
• Miyabashira J, Sekiguchi T, Nishimoto T (1995). "Mammalian cells have two functional RCC1 proteins produced by alternative splicing". J. Cell Sci. 107 (8): 2203–8. PMID 7983178.
• Noguchi E, Hayashi N, Azuma Y, et al. (1996). "Dis3, implicated in mitotic control, binds directly to Ran and enhances the GEF activity of RCC1". EMBO J. 15 (20): 5595–605. PMC 452304. PMID 8896453.
• Renault L, Nassar N, Vetter I, et al. (1998). "The 1.7 A crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller". Nature. 392 (6671): 97–101. Bibcode:1998Natur.392...97R. doi:10.1038/32204. PMID 9510255.
• Renault L, Nassar N, Wittinghofer A, et al. (1999). "Crystallization and preliminary X-ray analysis of human RCC1, the regulator of chromosome condensation". Acta Crystallogr. D. 55 (Pt 1): 272–5. doi:10.1107/S0907444998007768. PMID 10089422.
• Azuma Y, Renault L, García-Ranea JA, et al. (1999). "Model of the ran-RCC1 interaction using biochemical and docking experiments". J. Mol. Biol. 289 (4): 1119–30. doi:10.1006/jmbi.1999.2820. PMID 10369786.
• Talcott B, Moore MS (2000). "The nuclear import of RCC1 requires a specific nuclear localization sequence receptor, karyopherin alpha3/Qip". J. Biol. Chem. 275 (14): 10099–104. doi:10.1074/jbc.275.14.10099. PMID 10744690.
• Nemergut ME, Macara IG (2000). "Nuclear Import of the Ran Exchange Factor, Rcc1, Is Mediated by at Least Two Distinct Mechanisms". J. Cell Biol. 149 (4): 835–50. doi:10.1083/jcb.149.4.835. PMC 2174574. PMID 10811825.
• Fontoura BM, Blobel G, Yaseen NR (2000). "The nucleoporin Nup98 is a site for GDP/GTP exchange on ran and termination of karyopherin beta 2-mediated nuclear import". J. Biol. Chem. 275 (40): 31289–96. doi:10.1074/jbc.M004651200. PMID 10875935.
• Freire J, Covelo G, Sarandeses C, et al. (2001). "Identification of nuclear-import and cell-cycle regulatory proteins that bind to prothymosin alpha". Biochem. Cell Biol. 79 (2): 123–31. doi:10.1139/bcb-79-2-123. PMID 11310559.
• Renault L, Kuhlmann J, Henkel A, Wittinghofer A (2001). "Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1)". Cell. 105 (2): 245–55. doi:10.1016/S0092-8674(01)00315-4. PMID 11336674.
• Nemergut ME, Mizzen CA, Stukenberg T, et al. (2001). "Chromatin docking and exchange activity enhancement of RCC1 by histones H2A and H2B". Science. 292 (5521): 1540–3. Bibcode:2001Sci...292.1540N. doi:10.1126/science.292.5521.1540. PMID 11375490.
• Nemergut ME, Lindsay ME, Brownawell AM, Macara IG (2002). "Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor". J. Biol. Chem. 277 (20): 17385–8. doi:10.1074/jbc.C100620200. PMID 11932251.