R-4066

R-4066

File:R-4066.png
Gene therapy
Clinical data
Physiological data
Legal status
Pharmacokinetic data
Identifiers
IUPAC name N-(3,3-diphenyl-4-oxohex-1-yl)-7,8-benzo-3-azaspiro[5.5]undecane
CAS Number	101564-56-1
PubChem Template:Abbreviation	380029
Chemical and physical data
Formula	C32H37NO
Molar mass	451.641
3D model (JSmol)	Interactive image
SMILES CCC(=O)C(CCN1CCC2(CCCC3=CC=CC=C32)CC1)(C4=CC=CC=C4)C5=CC=CC=C5

Overview

R-4066 is a drug which is an analogue of the opioid analgesic methadone, where the metabolically labile dimethylamino group has been replaced by a piperidinospiro group. It is around 212x more potent than methadone as an analgesic in animal tests, with an effective oral dosage of 0.07mg/kg, but is slightly shorter acting, with a duration of action of around 3 hours.

R-4066 has never been used in humans, but would be expected to produce effects similar to those of other potent opioid agonists, including strong analgesia, sedation, euphoria, constipation, itching and respiratory depression which could be harmful or fatal.

References

Template:Opioids Template:WH Template:WS