Progeria classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]


Progeria may be classified according to genotype into two groups: Classic progeria and atypical progeria.


Group Classification of Hutchinson-Gilford Progeria Syndrome Cause
Group 1 Classic Hutchinson-Gilford progeria syndrome Due to nucleotide substitution in the lamin A/C gene LMNA(c.1824C>T [p.Gly608Gly])
Group 2 Atypical Hutchinson-Gilford progeria syndrome Due to a variety of pathogenic variants in intron 11 of the LMNA gene


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