Pirenzepine

Pirenzepine

Clinical data
ATC code	A02BX03 (WHO)
Identifiers
IUPAC name 11-[(4-Methylpiperazin-1yl)acetyl]6,11-dihydro-5H-pyrido[2,3-b][1,4]benzodiazepin-6-on
CAS Number	28797-61-7
PubChem CID	4848
DrugBank	APRD00515
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C19H21N5O2
Molar mass	351.403 g/mol

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Pirenzepine (marketed by Merck Marker under the trade-name Gastrozepin) is used in the treatment of peptic ulcers, as it reduces gastric acid secretion and reduces muscle spasm. It is in a class of drugs known as Muscarinic receptor antagonists - acetylcholine being the neurotransmitter of the parasympathetic nervous system which initiates the rest-and-digest state (as opposed to fight-or-flight), the result being an increase in gastric motility and digestion. It has no effects on the brain and spinal cord as it cannot diffuse through the blood-brain barrier.

Pirenzepine has been investigated for use in myopia control.