Paroxysmal cold hemoglobinuria causes

	Paroxysmal cold hemoglobinuria Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Kalsang Dolma, M.B.B.S.[2] Luke Rusowicz-Orazem, B.S.

Overview

PCH can be an after effect of an infection, when a microorganism triggers the formation of antibodies that cross-react with the P antigen on the red blood cell membrane. Viral infections that can cause PCH include measles, mumps, influenza, adenovirus,chickenpox, cytomegalovirus, and Epstein-Barr virus. Bacterial infections that can cause PCH include syphilis,Haemophilus influenzae and Mycoplasma pneumoniae. PCH can also be a side effect of some vaccinations. Chronic idiopathic(of unknown cause) PCH also occurs, but it is rare.

Causes

Common Causes

Causes by Organ System

Cardiovascular	No underlying causes
Chemical/Poisoning	No underlying causes
Dental	No underlying causes
Dermatologic	No underlying causes
Drug Side Effect	No underlying causes
Ear Nose Throat	No underlying causes
Endocrine	No underlying causes
Environmental	No underlying causes
Gastroenterologic	No underlying causes
Genetic	No underlying causes
Hematologic	Chronic lymphocytic leukemia, Chronic lymphocytic lymphoma, Hemolysis, Myelodysplastic syndrome, Non-hodgkin lymphoma, Primary myelofibrosis , Pulmonary small cell carcinoma
Iatrogenic	Measles vaccination, Vaccinations
Infectious Disease	Adenovirus, Chickenpox, Coxsackie a9, Cytomegalovirus, Epstein-barr virus, Escherichia coli, Haemophilus influenzae, Influenza, Klebsiella pneumoniae, Measles, Mumps, Mycoplasma pneumoniae, Parvovirus b19, Secondary syphilis, Tertiary syphilis, Treponema pallidum, Varicella-zoster virus , Visceral leishmaniasis
Musculoskeletal/Orthopedic	No underlying causes
Neurologic	No underlying causes
Nutritional/Metabolic	No underlying causes
Obstetric/Gynecologic	No underlying causes
Oncologic	Chronic lymphocytic leukemia, Chronic lymphocytic lymphoma, Myelodysplastic syndrome, Non-hodgkin lymphoma, Primary myelofibrosis , Pulmonary small cell carcinoma
Ophthalmologic	No underlying causes
Overdose/Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	No underlying causes
Renal/Electrolyte	No underlying causes
Rheumatology/Immunology/Allergy	No underlying causes
Sexual	Secondary syphilis, Tertiary syphilis
Trauma	No underlying causes
Urologic	No underlying causes
Miscellaneous	Idiopathic

Causes in Alphabetical Order

References

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