Parathyroid cancer historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]


Parathyroid cancer was first described by Sainton and Millot, in 1933. In 1928, the first parathyroidectomy operation was conducted by Isaac Y. Olch to treat parathyroid lesions.


  • In 1904, Dr. Fritz de Quevain first mentioned the term parathyroid cancer when he observed a non-functioning parathyroid lesion in one of his patients.[1]
  • Parathyroid cancer was first described in 1933 by Sainton and Millot.[2]

Landmark Events in the Development of Treatment Strategies

  • The first successful removal of the parathyroid may have been carried out in 1928 by doctor Isaac Y. Olch, whose intern had noticed elevated calcium levels in an elderly patient who complained of muscle weakness. Prior to this surgery, patients with removed parathyroid gland typically died from muscular tetany.[3]


  1. Quervain, F. (1909). "Parastruma maligna aberrata". Deutsche Zeitschrift für Chirurgie. 100 (1): 334–353. doi:10.1007/BF02819737. ISSN 0367-0023.
  2. McClenaghan F, Qureshi YA (2015). "Parathyroid cancer". Gland Surg. 4 (4): 329–38. doi:10.3978/j.issn.2227-684X.2015.05.09. PMC 4523631. PMID 26312219.
  3. Parathyroid gland. Wikipedia (2015). Accessed on December 28, 2015

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