PSCD1

Pleckstrin homology, Sec7 and coiled-coil domains 1(cytohesin 1)
File:PBB Protein PSCD1 image.jpg PDB rendering based on 1bc9.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1bc9​, 1u2b​
Identifiers
Symbols	PSCD1 ; B2-1; CYTOHESIN-1; D17S811E; FLJ34050; FLJ41900; SEC7
External IDs	Template:OMIM5 Template:MGI HomoloGene: 31262
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PSCD1 202880 s at tn.png
File:PBB GE PSCD1 202879 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Pleckstrin homology, Sec7 and coiled-coil domains 1(cytohesin 1), also known as PSCD1, is a human gene.

Pleckstrin homology, Sec7 and coiled/coil domains 1 (PSCD1) is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The PSCD1 is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. PSCD1 protein is 83% homologous to PSCD2.

Further reading

• Liu L, Pohajdak B (1992). "Cloning and sequencing of a human cDNA from cytolytic NK/T cells with homology to yeast SEC7". Biochim. Biophys. Acta. 1132 (1): 75–8. PMID 1511013.
• Dixon B, Mansour M, Pohajdak B (1993). "Assignment of human B2-1 gene (D17S811E) to chromosome 17qter by PCR analysis of somatic cell hybrids and fluorescence in situ hybridization". Cytogenet. Cell Genet. 63 (1): 42–4. PMID 8449036.CS1 maint: Multiple names: authors list (link)
• Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kolanus W, Nagel W, Schiller B; et al. (1996). "Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule". Cell. 86 (2): 233–42. PMID 8706128.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Meacci E, Tsai SC, Adamik R; et al. (1997). "Cytohesin-1, a cytosolic guanine nucleotide-exchange protein for ADP-ribosylation factor". Proc. Natl. Acad. Sci. U.S.A. 94 (5): 1745–8. PMID 9050849.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yu W, Andersson B, Worley KC; et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. PMID 9110174.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagel W, Zeitlmann L, Schilcher P; et al. (1998). "Phosphoinositide 3-OH kinase activates the beta2 integrin adhesion pathway and induces membrane recruitment of cytohesin-1". J. Biol. Chem. 273 (24): 14853–61. PMID 9614087.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Betz SF, Schnuchel A, Wang H; et al. (1998). "Solution structure of the cytohesin-1 (B2-1) Sec7 domain and its interaction with the GTPase ADP ribosylation factor 1". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 7909–14. PMID 9653114.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagel W, Schilcher P, Zeitlmann L, Kolanus W (1998). "The PH domain and the polybasic c domain of cytohesin-1 cooperate specifically in plasma membrane association and cellular function". Mol. Biol. Cell. 9 (8): 1981–94. PMID 9693361.CS1 maint: Multiple names: authors list (link)
• Pacheco-Rodriguez G, Meacci E, Vitale N; et al. (1998). "Guanine nucleotide exchange on ADP-ribosylation factors catalyzed by cytohesin-1 and its Sec7 domain". J. Biol. Chem. 273 (41): 26543–8. PMID 9756891.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rietzler M, Bittner M, Kolanus W; et al. (1998). "The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins". J. Biol. Chem. 273 (42): 27459–66. PMID 9765275.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schürmann A, Schmidt M, Asmus M; et al. (1999). "The ADP-ribosylation factor (ARF)-related GTPase ARF-related protein binds to the ARF-specific guanine nucleotide exchange factor cytohesin and inhibits the ARF-dependent activation of phospholipase D.". J. Biol. Chem. 274 (14): 9744–51. PMID 10092663.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pacheco-Rodriguez G, Patton WA, Adamik R; et al. (1999). "Structural elements of ADP-ribosylation factor 1 required for functional interaction with cytohesin-1". J. Biol. Chem. 274 (18): 12438–44. PMID 10212218.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Venkateswarlu K, Gunn-Moore F, Tavaré JM, Cullen PJ (1999). "EGF-and NGF-stimulated translocation of cytohesin-1 to the plasma membrane of PC12 cells requires PI 3-kinase activation and a functional cytohesin-1 PH domain". J. Cell. Sci. 112 ( Pt 12): 1957–65. PMID 10341214.CS1 maint: Multiple names: authors list (link)
• Ogasawara M, Kim SC, Adamik R; et al. (2000). "Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors". J. Biol. Chem. 275 (5): 3221–30. PMID 10652308.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vitale N, Pacheco-Rodriguez G, Ferrans VJ; et al. (2000). "Specific functional interaction of human cytohesin-1 and ADP-ribosylation factor domain protein (ARD1)". J. Biol. Chem. 275 (28): 21331–9. doi:10.1074/jbc.M909642199. PMID 10748148.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee SY, Mansour M, Pohajdak B (2000). "B2-1, a Sec7- and pleckstrin homology domain-containing protein, localizes to the Golgi complex". Exp. Cell Res. 256 (2): 515–21. doi:10.1006/excr.2000.4845. PMID 10772823.CS1 maint: Multiple names: authors list (link)
• Geiger C, Nagel W, Boehm T; et al. (2000). "Cytohesin-1 regulates beta-2 integrin-mediated adhesion through both ARF-GEF function and interaction with LFA-1". EMBO J. 19 (11): 2525–36. doi:10.1093/emboj/19.11.2525. PMID 10835351.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dierks H, Kolanus J, Kolanus W (2001). "Actin cytoskeletal association of cytohesin-1 is regulated by specific phosphorylation of its carboxyl-terminal polybasic domain". J. Biol. Chem. 276 (40): 37472–81. doi:10.1074/jbc.M101502200. PMID 11438522.CS1 maint: Multiple names: authors list (link)
• Tang P, Cheng TP, Agnello D; et al. (2002). "Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2625–9. doi:10.1073/pnas.052712999. PMID 11867758.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)