PGF (gene)

Placental growth factor, vascular endothelial growth factor-related protein
File:PBB Protein PGF image.jpg PDB rendering based on 1rv6.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1rv6​
Identifiers
Symbols	PGF ; PLGF; PlGF-2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1978
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PGF 209652 s at tn.png
File:PBB GE PGF 215179 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Placental growth factor, vascular endothelial growth factor-related protein, also known as PGF, is a human gene.

Further reading

• Luttun A, Tjwa M, Carmeliet P (2003). "Placental growth factor (PlGF) and its receptor Flt-1 (VEGFR-1): novel therapeutic targets for angiogenic disorders". Ann. N. Y. Acad. Sci. 979: 80–93. PMID 12543719.CS1 maint: Multiple names: authors list (link)
• Maglione D, Guerriero V, Viglietto G; et al. (1991). "Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor". Proc. Natl. Acad. Sci. U.S.A. 88 (20): 9267–71. PMID 1924389.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maglione D, Guerriero V, Viglietto G; et al. (1993). "Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14". Oncogene. 8 (4): 925–31. PMID 7681160.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Park JE, Chen HH, Winer J; et al. (1994). "Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR". J. Biol. Chem. 269 (41): 25646–54. PMID 7929268.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hauser S, Weich HA (1994). "A heparin-binding form of placenta growth factor (PlGF-2) is expressed in human umbilical vein endothelial cells and in placenta". Growth Factors. 9 (4): 259–68. PMID 8148155.
• Mattei MG, Borg JP, Rosnet O; et al. (1996). "Assignment of vascular endothelial growth factor (VEGF) and placenta growth factor (PLGF) genes to human chromosome 6p12-p21 and 14q24-q31 regions, respectively". Genomics. 32 (1): 168–9. doi:10.1006/geno.1996.0098. PMID 8786112.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ziche M, Maglione D, Ribatti D; et al. (1997). "Placenta growth factor-1 is chemotactic, mitogenic, and angiogenic". Lab. Invest. 76 (4): 517–31. PMID 9111514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vuorela P, Hatva E, Lymboussaki A; et al. (1997). "Expression of vascular endothelial growth factor and placenta growth factor in human placenta". Biol. Reprod. 56 (2): 489–94. PMID 9116151.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cao Y, Ji WR, Qi P; et al. (1997). "Placenta growth factor: identification and characterization of a novel isoform generated by RNA alternative splicing". Biochem. Biophys. Res. Commun. 235 (3): 493–8. doi:10.1006/bbrc.1997.6813. PMID 9207183.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Davis-Smyth T, Presta LG, Ferrara N (1998). "Mapping the charged residues in the second immunoglobulin-like domain of the vascular endothelial growth factor/placenta growth factor receptor Flt-1 required for binding and structural stability". J. Biol. Chem. 273 (6): 3216–22. PMID 9452434.CS1 maint: Multiple names: authors list (link)
• Landgren E, Schiller P, Cao Y, Claesson-Welsh L (1998). "Placenta growth factor stimulates MAP kinase and mitogenicity but not phospholipase C-gamma and migration of endothelial cells expressing Flt 1". Oncogene. 16 (3): 359–67. doi:10.1038/sj.onc.1201545. PMID 9467961.CS1 maint: Multiple names: authors list (link)
• Gluzman-Poltorak Z, Cohen T, Herzog Y, Neufeld G (2000). "Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected]". J. Biol. Chem. 275 (24): 18040–5. doi:10.1074/jbc.M909259199. PMID 10748121.CS1 maint: Multiple names: authors list (link)
• Renedo M, Arce I, Montgomery K; et al. (2000). "A sequence-ready physical map of the region containing the human natural killer gene complex on chromosome 12p12.3-p13.2". Genomics. 65 (2): 129–36. doi:10.1006/geno.2000.6163. PMID 10783260.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maglione D, Battisti M, Tucci M (2000). "Recombinant production of PIGF-1 and its activity in animal models". Farmaco. 55 (3): 165–7. PMID 10919072.CS1 maint: Multiple names: authors list (link)
• Roberts-Clark DJ, Smith AJ (2000). "Angiogenic growth factors in human dentine matrix". Arch. Oral Biol. 45 (11): 1013–6. PMID 11000388.
• Iyer S, Leonidas DD, Swaminathan GJ; et al. (2001). "The crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 A resolution". J. Biol. Chem. 276 (15): 12153–61. doi:10.1074/jbc.M008055200. PMID 11069911.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li XF, Charnock-Jones DS, Zhang E; et al. (2001). "Angiogenic growth factor messenger ribonucleic acids in uterine natural killer cells". J. Clin. Endocrinol. Metab. 86 (4): 1823–34. PMID 11297624.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Su YN, Hsu JJ, Lee CN; et al. (2002). "Raised maternal serum placenta growth factor concentration during the second trimester is associated with Down syndrome". Prenat. Diagn. 22 (1): 8–12. PMID 11810642.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Angelucci C, Lama G, Iacopino F; et al. (2002). "Effect of placenta growth factor-1 on proliferation and release of nitric oxide, cyclic AMP and cyclic GMP in human epithelial cells expressing the FLT-1 receptor". Growth Factors. 19 (3): 193–206. PMID 11811792.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mamluk R, Gechtman Z, Kutcher ME; et al. (2002). "Neuropilin-1 binds vascular endothelial growth factor 165, placenta growth factor-2, and heparin via its b1b2 domain". J. Biol. Chem. 277 (27): 24818–25. doi:10.1074/jbc.M200730200. PMID 11986311.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)