PAK7

P21(CDKN1A)-activated kinase 7
File:PBB Protein PAK7 image.jpg PDB rendering based on 2f57.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2f57​
Identifiers
Symbols	PAK7 ; PAK5; KIAA1264; MGC26232
External IDs	Template:OMIM5 Template:MGI HomoloGene: 22211
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PAK7 210721 s at tn.png
File:PBB GE PAK7 213990 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

P21(CDKN1A)-activated kinase 7, also known as PAK7, is a human gene.

The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described.

Further reading

• Jaffer ZM, Chernoff J (2002). "p21-activated kinases: three more join the Pak". Int. J. Biochem. Cell Biol. 34 (7): 713–7. PMID 11950587.
• del Peso L, González-García M, Page C; et al. (1997). "Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt". Science. 278 (5338): 687–9. PMID 9381178.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scheid MP, Schubert KM, Duronio V (1999). "Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase". J. Biol. Chem. 274 (43): 31108–13. PMID 10521512.CS1 maint: Multiple names: authors list (link)
• Nagase T, Ishikawa K, Kikuno R; et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. PMID 10574462.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tan Y, Demeter MR, Ruan H, Comb MJ (2000). "BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival". J. Biol. Chem. 275 (33): 25865–9. doi:10.1074/jbc.M004199200. PMID 10837486.CS1 maint: Multiple names: authors list (link)
• Lizcano JM, Morrice N, Cohen P (2001). "Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155". Biochem. J. 349 (Pt 2): 547–57. PMID 10880354.CS1 maint: Multiple names: authors list (link)
• Cau J, Faure S, Comps M; et al. (2002). "A novel p21-activated kinase binds the actin and microtubule networks and induces microtubule stabilization". J. Cell Biol. 155 (6): 1029–42. doi:10.1083/jcb.200104123. PMID 11733543.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dan C, Nath N, Liberto M, Minden A (2002). "PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells". Mol. Cell. Biol. 22 (2): 567–77. PMID 11756552.CS1 maint: Multiple names: authors list (link)
• Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pandey A, Dan I, Kristiansen TZ; et al. (2002). "Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain". Oncogene. 21 (24): 3939–48. doi:10.1038/sj.onc.1205478. PMID 12032833.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cotteret S, Jaffer ZM, Beeser A, Chernoff J (2003). "p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD". Mol. Cell. Biol. 23 (16): 5526–39. PMID 12897128.CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Matenia D, Griesshaber B, Li XY; et al. (2006). "PAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin". Mol. Biol. Cell. 16 (9): 4410–22. doi:10.1091/mbc.E05-01-0081. PMID 16014608.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cotteret S, Chernoff J (2006). "Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties". Mol. Cell. Biol. 26 (8): 3215–30. doi:10.1128/MCB.26.8.3215-3230.2006. PMID 16581795.
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)