Neomycin description
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Description
NEO-FRADIN Oral Solution for oral administration contains neomycin which is an antibiotic obtained from the metabolic products of the actinomycete Streptomyces fradiae. The pH range is 5.0 to 7.5. NEO-FRADIN Oral Solution is a clear orange solution with a cherry flavor. Each 5 mL of NEO-FRADIN Oral Solution contains 125 mg of neomycin sulfate (equivalent to 87.5 mg of neomycin).
Inactive ingredients: benzoic acid, FD&C yellow no. 6, cherry flavor, glycerin, methylparaben, proplyparaben, sodium phosphate dibasic heptahydrate, sulfuric acid, and purified water.
Sodium phosphate dibasic heptahydrate and sulfuric acid are used as pH adjusters.
The chemical name for Neomycin is: 0-2, 6-diamino-2, 6-dideoxy-α-D-lucopyranosyl-(1→3)- 0β-D-ribofuranosyl-(1→5)0-[2, 6-diamino-2, 6-dideoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-D-streptamine.
Neomycin B is identical except that the -α-D-glucopyranosyl residue in the neobiosamine moiety is β-L-idopyranosly. The molecular weight of Neomycin is 614.67. The structural formula is represented below:[1]
 |
References
Adapted from the FDA Package Insert.