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E number{{#property:P628}}
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Chemical and physical data
Molar mass185.27 g/mol

Naphthylisopropylamine (PAL-287) is a stimulant drug developed for the treatment of amphetamine and cocaine addiction. PAL-287 acts by releasing dopamine and serotonin.[1]

In animal studies, PAL-287 was shown to reduce cocaine self-administration, yet produced relatively little stimulant effect when administered by itself, being a weaker stimulant than the comparison drug dexamphetamine.[2] PAL-287 is now under development to see whether it is a useful substitute drug for treating stimulant addiction in humans.


  1. Rothman RB, Blough BE, Baumann MH. Dual dopamine/serotonin releasers as potential medications for stimulant and alcohol addictions. AAPS J. 2007 Jan 5;9(1):E1-10.
  2. Richard B. Rothman, Bruce E. Blough, William L. Woolverton, Karen G. Anderson, S. Stevens Negus, Nancy K. Mello, Bryan L. Roth, and Michael H. Baumann. Development of a Rationally Designed, Low Abuse Potential, Biogenic Amine Releaser That Suppresses Cocaine Self-Administration. Journal of Pharmacology And Experimental Therapeutics. 2005; 313: 1361-1369.

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