NUP88

Nucleoporin 88kDa
Identifiers
Symbols	NUP88 ; MGC8530
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1901
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE NUP88 202900 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Nucleoporin 88kDa, also known as NUP88, is a human gene.

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias.

Further reading

• Stoffler D, Fahrenkrog B, Aebi U (1999). "The nuclear pore complex: from molecular architecture to functional dynamics". Curr. Opin. Cell Biol. 11 (3): 391–401. doi:10.1016/S0955-0674(99)80055-6. PMID 10395558.CS1 maint: Multiple names: authors list (link)
• Hood JK, Silver PA (2000). "Diverse nuclear transport pathways regulate cell proliferation and oncogenesis". Biochim. Biophys. Acta. 1471 (1): M31–41. PMID 10967423.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Fornerod M, van Deursen J, van Baal S; et al. (1997). "The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88". EMBO J. 16 (4): 807–16. doi:10.1093/emboj/16.4.807. PMID 9049309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fornerod M, van Baal S, Valentine V; et al. (1997). "Chromosomal localization of genes encoding CAN/Nup214-interacting proteins--human CRM1 localizes to 2p16, whereas Nup88 localizes to 17p13 and is physically linked to SF2p32". Genomics. 42 (3): 538–40. doi:10.1006/geno.1997.4767. PMID 9205132.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Boer J, Bonten-Surtel J, Grosveld G (1998). "Overexpression of the nucleoporin CAN/NUP214 induces growth arrest, nucleocytoplasmic transport defects, and apoptosis". Mol. Cell. Biol. 18 (3): 1236–47. PMID 9488438.CS1 maint: Multiple names: authors list (link)
• Martínez N, Alonso A, Moragues MD; et al. (1999). "The nuclear pore complex protein Nup88 is overexpressed in tumor cells". Cancer Res. 59 (21): 5408–11. PMID 10554006.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gould VE, Martinez N, Orucevic A; et al. (2000). "A novel, nuclear pore-associated, widely distributed molecule overexpressed in oncogenesis and development". Am. J. Pathol. 157 (5): 1605–13. PMID 11073820.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wu X, Kasper LH, Mantcheva RT; et al. (2001). "Disruption of the FG nucleoporin NUP98 causes selective changes in nuclear pore complex stoichiometry and function". Proc. Natl. Acad. Sci. U.S.A. 98 (6): 3191–6. doi:10.1073/pnas.051631598. PMID 11248054.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gould VE, Orucevic A, Zentgraf H; et al. (2002). "Nup88 (karyoporin) in human malignant neoplasms and dysplasias: correlations of immunostaining of tissue sections, cytologic smears, and immunoblot analysis". Hum. Pathol. 33 (5): 536–44. PMID 12094380.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Griffis ER, Xu S, Powers MA (2003). "Nup98 localizes to both nuclear and cytoplasmic sides of the nuclear pore and binds to two distinct nucleoporin subcomplexes". Mol. Biol. Cell. 14 (2): 600–10. doi:10.1091/mbc.E02-09-0582. PMID 12589057.CS1 maint: Multiple names: authors list (link)
• Agudo D, Gómez-Esquer F, Martínez-Arribas F; et al. (2004). "Nup88 mRNA overexpression is associated with high aggressiveness of breast cancer". Int. J. Cancer. 109 (5): 717–20. doi:10.1002/ijc.20034. PMID 14999780.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schneider J, Linares R, Martínez-Arribas F; et al. (2004). "Developing chick embryos express a protein which shares homology with the nuclear pore complex protein Nup88 present in human tumors". Int. J. Dev. Biol. 48 (4): 339–42. doi:10.1387/ijdb.031748js. PMID 15300515.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bernad R, Engelsma D, Sanderson H; et al. (2006). "Nup214-Nup88 nucleoporin subcomplex is required for CRM1-mediated 60 S preribosomal nuclear export". J. Biol. Chem. 281 (28): 19378–86. doi:10.1074/jbc.M512585200. PMID 16675447.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Villén J, Gerber SA; et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)