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Nucleoporin 107kDa
Symbols NUP107 ; NUP84
External IDs Template:OMIM5 Template:MGI HomoloGene5555
RNA expression pattern
File:PBB GE NUP107 218768 at tn.png
More reference expression data
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Nucleoporin 107kDa, also known as NUP107, is a human gene.[1]

This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[1]


  1. 1.0 1.1 "Entrez Gene: NUP107 nucleoporin 107kDa".

Further reading

  • Bastos R, Ribas de Pouplana L, Enarson M; et al. (1997). "Nup84, a novel nucleoporin that is associated with CAN/Nup214 on the cytoplasmic face of the nuclear pore complex". J. Cell Biol. 137 (5): 989–1000. PMID 9166401.
  • Belgareh N, Rabut G, Baï SW; et al. (2001). "An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells". J. Cell Biol. 154 (6): 1147–60. doi:10.1083/jcb.200101081. PMID 11564755.
  • Vasu S, Shah S, Orjalo A; et al. (2001). "Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export". J. Cell Biol. 155 (3): 339–54. doi:10.1083/jcb.200108007. PMID 11684705.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Boehmer T, Enninga J, Dales S; et al. (2003). "Depletion of a single nucleoporin, Nup107, prevents the assembly of a subset of nucleoporins into the nuclear pore complex". Proc. Natl. Acad. Sci. U.S.A. 100 (3): 981–5. doi:10.1073/pnas.252749899. PMID 12552102.
  • Walther TC, Alves A, Pickersgill H; et al. (2003). "The conserved Nup107-160 complex is critical for nuclear pore complex assembly". Cell. 113 (2): 195–206. PMID 12705868.
  • Walther TC, Askjaer P, Gentzel M; et al. (2003). "RanGTP mediates nuclear pore complex assembly". Nature. 424 (6949): 689–94. doi:10.1038/nature01898. PMID 12894213.
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Loïodice I, Alves A, Rabut G; et al. (2005). "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis". Mol. Biol. Cell. 15 (7): 3333–44. doi:10.1091/mbc.E03-12-0878. PMID 15146057.
  • Krull S, Thyberg J, Björkroth B; et al. (2005). "Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket". Mol. Biol. Cell. 15 (9): 4261–77. doi:10.1091/mbc.E04-03-0165. PMID 15229283.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
  • Berke IC, Boehmer T, Blobel G, Schwartz TU (2005). "Structural and functional analysis of Nup133 domains reveals modular building blocks of the nuclear pore complex". J. Cell Biol. 167 (4): 591–7. doi:10.1083/jcb.200408109. PMID 15557116.
  • Nousiainen M, Silljé HH, Sauer G; et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMID 16565220.
  • Orjalo AV, Arnaoutov A, Shen Z; et al. (2006). "The Nup107-160 nucleoporin complex is required for correct bipolar spindle assembly". Mol. Biol. Cell. 17 (9): 3806–18. doi:10.1091/mbc.E05-11-1061. PMID 16807356.
  • Beausoleil SA, Villén J, Gerber SA; et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
  • Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Glavy JS, Krutchinsky AN, Cristea IM; et al. (2007). "Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex". Proc. Natl. Acad. Sci. U.S.A. 104 (10): 3811–6. doi:10.1073/pnas.0700058104. PMID 17360435.
  • Zuccolo M, Alves A, Galy V; et al. (2007). "The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions". EMBO J. 26 (7): 1853–64. doi:10.1038/sj.emboj.7601642. PMID 17363900.
  • Boehmer T, Schwartz TU (2007). "Purification, crystallization and preliminary X-ray analysis of a Nup107-Nup133 heterodimeric nucleoporin complex". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 63 (Pt 9): 816–8. doi:10.1107/S1744309107040523. PMID 17768364.

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