Metanephric adenoma pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]

Overview

On gross pathology, a sharply circumscribed, nonencapsulated solitary mass is the characteristic finding of metanephric adenoma. On microscopic histopathological analysis, small uniform cells with fine chromatin and smooth nuclear membrane, variable architecture, and psammoma bodies are characteristic findings of metanephric adenoma.

Genetics

• Allelic changes of a tumor suppressor gene on chromosome 2p13 may be involved in the pathogenesis of metanephric adenoma.

Gross Pathology

Characteristic findings of metanephric adenoma on gross pathology include:

• Solitary mass
• Sharply circumscribed
• Not encapsulated

Microscopic Pathology

The characteristics of metanephric adenomas include:

• Small uniform cells with:

• Fine chromatin
• No apparent nucleolus
• Smooth nuclear membrane

• Variable architecture:

• May be sheets, ductal or micropapillary

• Psammoma bodies may be present

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  Metanephric adenoma