Melanoma Genetic Counselling

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Anum Ijaz M.B.B.S., M.D.[2]

Overview

The American Academy of Dermatology (AAD) suggests that some patients with primary cutaneous melanoma (CM) may benefit from genetic counseling if certain criteria are met. Whereas genetic testing decisions are best made on a case-by-case basis, taking into account various factors such as family history, cancer patterns, patient preferences, and weighing risks against benefits.

2019 AAD Recommendations for Genetic Counseling of patients with CM

Class C

Cancer risk counseling by a qualified genetic counselor is recommended for patients with CM who have: A family history of invasive CM or pancreatic cancer (≥3 affected members on 1 side of the family) Multiple primary invasive CM (≥3), including 1 early-onset tumor (at age <45 y) ≥1 MBAIT and a family history of mesothelioma, meningioma, and/or uveal melanoma ≥2 MBAITs (Level of Evidence:Ⅲ )

*- CM = cutaneous melanoma; MBAIT = melanocytic BAP1-mutated atypical intradermal tumor.

Reference

Swetter SM, Tsao H, Bichakjian CK, Curiel-Lewandrowski C, Elder DE, Gershenwald JE, Guild V, Grant-Kels JM, Halpern AC, Johnson TM, Sober AJ, Thompson JA, Wisco OJ, Wyatt S, Hu S, Lamina T (January 2019). "Guidelines of care for the management of primary cutaneous melanoma". J Am Acad Dermatol. 80 (1): 208–250. doi:10.1016/j.jaad.2018.08.055. PMID 30392755.