Melanoma historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Yazan Daaboul, M.D.; Serge Korjian M.D.

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Melanoma was first described by Hippocrates in the 5th century BC. It was often described as the fatal black tumor. In 1838, the term melanoma was first proposed by Sir Robert Carswell, a British pathologist. In 1956, Henry Lancaster, an Australian mathematician, was the first to discover the association between UV radiation exposure and development of melanoma. In 2003, BRAF mutations were first identified in the pathogenesis of melanoma.

Historical Perspective



  1. 1.0 1.1 Karamanou M, Liappas I, Stamboulis E, Lymperi M, Kyriakis K, Androutsos G (2012). "Sir Robert Carswell (1793-1857): coining the term "melanoma"". J BUON. 17 (2): 400–2. PMID 22740229.
  2. Urteaga O, Pack GT (1966). "On the antiquity of melanoma". Cancer. 19 (5): 607–10. PMID 5326247.
  3. Norris W. (1820). "Case of fungoid disease". Edinb Med Surg J. 16: 562–565.
  4. 4.0 4.1 4.2 4.3 Rebecca VW, Sondak VK, Smalley KS (2012). "A brief history of melanoma: from mummies to mutations". Melanoma Res. 22 (2): 114–22. doi:10.1097/CMR.0b013e328351fa4d. PMC 3303163. PMID 22395415.
  5. LANCASTER HO (1956). "Some geographical aspects of the mortality from melanoma in Europeans". Med J Aust. 43 (26): 1082–7. PMID 13347440.
  6. Michaloglou C, Vredeveld LC, Soengas MS, Denoyelle C, Kuilman T, van der Horst CM; et al. (2005). "BRAFE600-associated senescence-like cell cycle arrest of human naevi". Nature. 436 (7051): 720–4. doi:10.1038/nature03890. PMID 16079850.
  7. Breslow A, Macht SD (1977). "Optimal size of resection margin for thin cutaneous melanoma". Surg Gynecol Obstet. 145 (5): 691–2. PMID 910211.

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